AbstractRas expression in human epithelial cells with integrated HPV genomes has been shown to cause tumorigenic transformation. The effects of Ras in cells representing early stage HPV-associated disease (i.e., when HPV is extrachromosomal and the oncogenes are under control of native promoters) have not been examined. Here, we used human cervical keratinocyte cell lines containing stably replicating extrachromosomal HPV-16 and present the novel finding that these cells resist transformation by oncogenic H-Ras. Ras expression consistently diminished anchorage-independent growth (AI), reduced E6 and E7 expression, and caused p53 induction in these cells. Conversely, AI was enhanced or maintained in Ras-transduced cervical cells that were im...
AbstractHuman papillomaviruses (HPV) 16 is a DNA virus encoding three oncogenes — E5, E6, and E7. Th...
The stratified squamous epithelium (SSE; for abbreviations, see lists on page xviii) in the transfor...
AbstractActivation of the productive phase of the human papillomavirus (HPV) life cycle in different...
AbstractRas expression in human epithelial cells with integrated HPV genomes has been shown to cause...
AbstractStudies of changes in the virus and host cell upon progression from human papillomavirus (HP...
AbstractPersistent infections with human papillomaviruses type 18 can result in the development of c...
AbstractHuman papillomavirus type 16 (HPV-16) is the most common papillomavirus genome found in huma...
Journal URL: http://www.spandidos-publications.com/ijo/Compatible with the epidemiology and natural ...
Human papillomavirus (HPV) causes about 5% of all human cancers. The HPV oncoproteins E6/E7 are resp...
Head and Neck Squamous Carcinoma (HNSCC) is one of the most common cancers worldwide. HNSCC affects ...
E7 oncoproteins of mucosal high-risk human papillomavirus type 16 and 18 (HPV16 and HPV18) immortali...
AbstractAmong human papillomavirus (HPV) types, clinical association with benign vs malignant lesion...
Human papillomavirus is the causative agent of the 2nd highest occurring cancer in women, cervical c...
The human papillomavirus type 16 (HPV-16) E7 gene cooperates with an activated ras oncogene to trans...
AbstractThe transforming potential of the human papillomavirus (HPV) type 16 has been defined largel...
AbstractHuman papillomaviruses (HPV) 16 is a DNA virus encoding three oncogenes — E5, E6, and E7. Th...
The stratified squamous epithelium (SSE; for abbreviations, see lists on page xviii) in the transfor...
AbstractActivation of the productive phase of the human papillomavirus (HPV) life cycle in different...
AbstractRas expression in human epithelial cells with integrated HPV genomes has been shown to cause...
AbstractStudies of changes in the virus and host cell upon progression from human papillomavirus (HP...
AbstractPersistent infections with human papillomaviruses type 18 can result in the development of c...
AbstractHuman papillomavirus type 16 (HPV-16) is the most common papillomavirus genome found in huma...
Journal URL: http://www.spandidos-publications.com/ijo/Compatible with the epidemiology and natural ...
Human papillomavirus (HPV) causes about 5% of all human cancers. The HPV oncoproteins E6/E7 are resp...
Head and Neck Squamous Carcinoma (HNSCC) is one of the most common cancers worldwide. HNSCC affects ...
E7 oncoproteins of mucosal high-risk human papillomavirus type 16 and 18 (HPV16 and HPV18) immortali...
AbstractAmong human papillomavirus (HPV) types, clinical association with benign vs malignant lesion...
Human papillomavirus is the causative agent of the 2nd highest occurring cancer in women, cervical c...
The human papillomavirus type 16 (HPV-16) E7 gene cooperates with an activated ras oncogene to trans...
AbstractThe transforming potential of the human papillomavirus (HPV) type 16 has been defined largel...
AbstractHuman papillomaviruses (HPV) 16 is a DNA virus encoding three oncogenes — E5, E6, and E7. Th...
The stratified squamous epithelium (SSE; for abbreviations, see lists on page xviii) in the transfor...
AbstractActivation of the productive phase of the human papillomavirus (HPV) life cycle in different...