SummaryIn Burkitt lymphoma (BL), a germinal center B-cell-derived tumor, the pro-apoptotic properties of c-MYC must be counterbalanced. Predicting that survival signals would be delivered by phosphoinositide-3-kinase (PI3K), a major survival determinant in mature B cells, we indeed found that combining constitutive c-MYC expression and PI3K activity in germinal center B cells of the mouse led to BL-like tumors, which fully phenocopy human BL with regard to histology, surface and other markers, and gene expression profile. The tumors also accumulate tertiary mutational events, some of which are recurrent in the human disease. These results and our finding of recurrent PI3K pathway activation in human BL indicate that deregulated c-MYC and PI...
Burkitt's lymphoma (BL), driven by translocation and overexpression of the c-MYC gene, is an aggress...
http://www.jimmunol.org/cgi/content/full/179/9/6033Burkitt lymphoma (BL) features translocations lin...
Burkitt’s lymphoma (BL) is an aggressive B cell neoplasm that is characterized by a chromosomal tra...
SummaryIn Burkitt lymphoma (BL), a germinal center B-cell-derived tumor, the pro-apoptotic propertie...
In Burkitt lymphoma (BL), a germinal center B-cell-derived tumor, the pro-apoptotic properties of c-...
Burkitt's lymphoma (BL) is an aggressive disorder associated with extremely high rates of cell proli...
Burkitt's lymphoma (BL) is an aggressive disorder associated with extremely high rates of cell proli...
Lindsay C Spender, Gareth J Inman Division of Cancer Research, Medical Research Institute, Jacqui Wo...
Chromosomal translocations causing deregulated c-MYC expression are detectable in most Burkitt lymph...
Background A promising therapeutic approach for aggressive B-cell Non-Hodgkin lymphoma (NHL), includ...
BACKGROUND: Myc is a well known driver of lymphomagenesis, and Myc-activating chromosomal translocat...
© 2011 Dr. Jake ShorttThe phosphatidylinositol-3-kinase (PI3K) / mammalian target of rapamycin (mTOR...
Burkitt's lymphoma (BL), driven by translocation and overexpression of the c-MYC gene, is an aggress...
Oncogenic activation of MYC drives cell proliferation in Burkitt lymphoma (BL), but also evokes stre...
Phosphoinositide 3-kinase (PI3K) and Myc are known to cooperate in promoting the survival and growth...
Burkitt's lymphoma (BL), driven by translocation and overexpression of the c-MYC gene, is an aggress...
http://www.jimmunol.org/cgi/content/full/179/9/6033Burkitt lymphoma (BL) features translocations lin...
Burkitt’s lymphoma (BL) is an aggressive B cell neoplasm that is characterized by a chromosomal tra...
SummaryIn Burkitt lymphoma (BL), a germinal center B-cell-derived tumor, the pro-apoptotic propertie...
In Burkitt lymphoma (BL), a germinal center B-cell-derived tumor, the pro-apoptotic properties of c-...
Burkitt's lymphoma (BL) is an aggressive disorder associated with extremely high rates of cell proli...
Burkitt's lymphoma (BL) is an aggressive disorder associated with extremely high rates of cell proli...
Lindsay C Spender, Gareth J Inman Division of Cancer Research, Medical Research Institute, Jacqui Wo...
Chromosomal translocations causing deregulated c-MYC expression are detectable in most Burkitt lymph...
Background A promising therapeutic approach for aggressive B-cell Non-Hodgkin lymphoma (NHL), includ...
BACKGROUND: Myc is a well known driver of lymphomagenesis, and Myc-activating chromosomal translocat...
© 2011 Dr. Jake ShorttThe phosphatidylinositol-3-kinase (PI3K) / mammalian target of rapamycin (mTOR...
Burkitt's lymphoma (BL), driven by translocation and overexpression of the c-MYC gene, is an aggress...
Oncogenic activation of MYC drives cell proliferation in Burkitt lymphoma (BL), but also evokes stre...
Phosphoinositide 3-kinase (PI3K) and Myc are known to cooperate in promoting the survival and growth...
Burkitt's lymphoma (BL), driven by translocation and overexpression of the c-MYC gene, is an aggress...
http://www.jimmunol.org/cgi/content/full/179/9/6033Burkitt lymphoma (BL) features translocations lin...
Burkitt’s lymphoma (BL) is an aggressive B cell neoplasm that is characterized by a chromosomal tra...