SummaryPathogens utilize features of the host response as cues to regulate virulence gene expression. Salmonella enterica serovar Typhimurium (ST) sense Toll-like receptor (TLR)-dependent signals to induce Salmonella Pathogenicity Island 2 (SPI2), a locus required for intracellular replication. To examine pathogenicity in the absence of such cues, we evaluated ST virulence in mice lacking all TLR function (Tlr2−/−xTlr4−/−xUnc93b13d/3d). When delivered systemically to TLR-deficient mice, ST do not require SPI2 and maintain virulence by replicating extracellularly. In contrast, SPI2 mutant ST are highly attenuated after oral infection of the same mice, revealing a role for SPI2 in the earliest stages of infection, even when intracellular repl...
Bacterial pathogens must sense and respond to newly encountered host environments to regulate the ex...
SummaryThe virulence of Salmonella is linked to its invasive capacity and suppression of adaptive im...
<div><p>The intracellular pathogen <i>Salmonella enterica</i> serovar Typhimurium causes intestinal ...
SummaryPathogens utilize features of the host response as cues to regulate virulence gene expression...
Pathogens utilize features of the host response as cues to regulate virulence gene expression. Salmo...
SummaryToll-like receptors (TLRs) contribute to host resistance to microbial pathogens and can drive...
Toll-like receptors (TLRs) contribute to host resistance to microbial pathogens and drive the evolut...
Salmonella survives in macrophages by using a molecular syringe to deliver proteins into the host-ce...
Salmonella typhimurium can colonize the gut, invade intestinal tissues, and cause enterocolitis. In ...
The bacterial species Salmonella enterica consists of a collection of closely related enteric bacter...
SummarySalmonella spp. are gram-negative flagellated bacteria that can cause food- and waterborne ga...
To cause a systemic infection, Salmonella must respond to many environmental cues during mouse infec...
The innate immune system provides the first line of defense against invading microorganisms by induc...
<p>(a) The intracellular life of <i>Salmonella</i>. Invasion of phagocytic and non-phagocytic cells....
Salmonella enterica serovar Typhimurium (S. Typhimurium) uses two-component regulatory systems (TCRS...
Bacterial pathogens must sense and respond to newly encountered host environments to regulate the ex...
SummaryThe virulence of Salmonella is linked to its invasive capacity and suppression of adaptive im...
<div><p>The intracellular pathogen <i>Salmonella enterica</i> serovar Typhimurium causes intestinal ...
SummaryPathogens utilize features of the host response as cues to regulate virulence gene expression...
Pathogens utilize features of the host response as cues to regulate virulence gene expression. Salmo...
SummaryToll-like receptors (TLRs) contribute to host resistance to microbial pathogens and can drive...
Toll-like receptors (TLRs) contribute to host resistance to microbial pathogens and drive the evolut...
Salmonella survives in macrophages by using a molecular syringe to deliver proteins into the host-ce...
Salmonella typhimurium can colonize the gut, invade intestinal tissues, and cause enterocolitis. In ...
The bacterial species Salmonella enterica consists of a collection of closely related enteric bacter...
SummarySalmonella spp. are gram-negative flagellated bacteria that can cause food- and waterborne ga...
To cause a systemic infection, Salmonella must respond to many environmental cues during mouse infec...
The innate immune system provides the first line of defense against invading microorganisms by induc...
<p>(a) The intracellular life of <i>Salmonella</i>. Invasion of phagocytic and non-phagocytic cells....
Salmonella enterica serovar Typhimurium (S. Typhimurium) uses two-component regulatory systems (TCRS...
Bacterial pathogens must sense and respond to newly encountered host environments to regulate the ex...
SummaryThe virulence of Salmonella is linked to its invasive capacity and suppression of adaptive im...
<div><p>The intracellular pathogen <i>Salmonella enterica</i> serovar Typhimurium causes intestinal ...