AbstractUnsaturated fatty acids (oleic acid and arachidonic acid) activate purified protein kinase C independently of phospholipid and Ca2+. Oleic acid activation of protein kinase C is as effective as phosphatidylserine and Ca2+. Ka, values for oleic acid and arachidonic acid are 50 and 53 μM, respectively. In contrast to the cis fatty acids, a trans form (elaidic acid) or a saturated fatty acid (stearic acid) has little or no effect on protein kinase C activation. If cis fatty acid liberation is physiologically important, this suggests that another mechanism may exist for protein kinase C activation, in addition to phospholipase C/phosphatidylinositol turnover signaling, possibly via the liberation of cis fatty acids by the Ca2+-dependent...
AbstractThe γ-subspecies of protein kinase C (PKC) apparently is expressed only in central nervous t...
AbstractSynaptosomes isolated from the rat hippocampus contain the α- and β-subspecies of protein ki...
AbstractThe mechanisms underlying arachidonic acid (AA) release by uterine stromal (UIII) cells were...
Both cis- and trans-unsaturated but not saturated fatty acids activated protein kinase C purified to...
The kinetics of activation of protein kinase C by oleic acid have been reinvestigated, using highly ...
AbstractType II and type III isoenzymes of protein kinase C isolated from rabbit thymus cells were a...
AbstractThe ability of arachidonic acid and other fatty acids to induce phosphorylation of endogenou...
The physiological importance of protein kinase C (PKC) activation is widely appreciated and well doc...
Octadecadienoic acids (linoleic acid and linolelaidic acid) and the diacylglycerol, 1-oleoyl-2-acety...
AbstractUnsaturated fatty acids (oleic, linoleic and arachidonic acids) markedly activate extensivel...
Phosphatidic acid (PA) is produced rapidly in agonist-stimulated cells, but the physiological functi...
AbstractA calcium-independent but 12-O-tetradecanoylphorbol-13-acetate (TPA)- or diacylglycerol-acti...
Abstract — 3-Trifluoromethylphenyldiazirine based oleic acids derivatives are synthesized to elucida...
AbstractPretreatment of protein kinase C with 12-O-tetradecanoylphorbol-13-acetate (TPA) and phospho...
AbstractProtein kinase C (PKC) from a human megakaryoblastic leukemic cell line (MEG-01) was resolve...
AbstractThe γ-subspecies of protein kinase C (PKC) apparently is expressed only in central nervous t...
AbstractSynaptosomes isolated from the rat hippocampus contain the α- and β-subspecies of protein ki...
AbstractThe mechanisms underlying arachidonic acid (AA) release by uterine stromal (UIII) cells were...
Both cis- and trans-unsaturated but not saturated fatty acids activated protein kinase C purified to...
The kinetics of activation of protein kinase C by oleic acid have been reinvestigated, using highly ...
AbstractType II and type III isoenzymes of protein kinase C isolated from rabbit thymus cells were a...
AbstractThe ability of arachidonic acid and other fatty acids to induce phosphorylation of endogenou...
The physiological importance of protein kinase C (PKC) activation is widely appreciated and well doc...
Octadecadienoic acids (linoleic acid and linolelaidic acid) and the diacylglycerol, 1-oleoyl-2-acety...
AbstractUnsaturated fatty acids (oleic, linoleic and arachidonic acids) markedly activate extensivel...
Phosphatidic acid (PA) is produced rapidly in agonist-stimulated cells, but the physiological functi...
AbstractA calcium-independent but 12-O-tetradecanoylphorbol-13-acetate (TPA)- or diacylglycerol-acti...
Abstract — 3-Trifluoromethylphenyldiazirine based oleic acids derivatives are synthesized to elucida...
AbstractPretreatment of protein kinase C with 12-O-tetradecanoylphorbol-13-acetate (TPA) and phospho...
AbstractProtein kinase C (PKC) from a human megakaryoblastic leukemic cell line (MEG-01) was resolve...
AbstractThe γ-subspecies of protein kinase C (PKC) apparently is expressed only in central nervous t...
AbstractSynaptosomes isolated from the rat hippocampus contain the α- and β-subspecies of protein ki...
AbstractThe mechanisms underlying arachidonic acid (AA) release by uterine stromal (UIII) cells were...