SummaryInsulin resistance, tissue inflammation, and adipose tissue dysfunction are features of obesity and Type 2 diabetes. We generated adipocyte-specific Nuclear Receptor Corepressor (NCoR) knockout (AKO) mice to investigate the function of NCoR in adipocyte biology, glucose and insulin homeostasis. Despite increased obesity, glucose tolerance was improved in AKO mice, and clamp studies demonstrated enhanced insulin sensitivity in liver, muscle, and fat. Adipose tissue macrophage infiltration and inflammation were also decreased. PPARγ response genes were upregulated in adipose tissue from AKO mice and CDK5-mediated PPARγ ser-273 phosphorylation was reduced, creating a constitutively active PPARγ state. This identifies NCoR as an adaptor ...
The nuclear receptor PPARα is associated with reducing adiposity, especially in the liver, where it ...
AbstractIn contrast to the well-established roles of PPARγ and PPARα in lipid metabolism, little is ...
SummaryInsulin stimulates glucose uptake through the membrane translocation of GLUT4 and GLUT1. Pero...
AbstractAdipocytes are highly specialized cells that play a central role in lipid homeostasis and th...
AbstractObesity-associated diabetes is epidemic in industrialized societies. The nuclear receptor pe...
SummaryMacrophage-mediated inflammation is a major contributor to obesity-associated insulin resista...
Adipose tissue is an important fat-storage and endocrine organ, whose dysfunction is closely associa...
SummaryThe role of the peroxisome proliferator-activated receptor-α (PPARα) in the development of in...
Objective: Adipose tissue is the primary site for lipid deposition that protects the organisms in ca...
Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a master regulator of adipose tissu...
Chronic inflammation in adipose tissue is highly associated with insulin resistance. Herein, we demo...
OBJECTIVE: Chronic activation of the nuclear factor-kappaB (NF-kappaB) in white adipose tissue leads...
Peroxisome proliferator receptor gamma (PPARγ) is a nuclear receptor first identified for its role i...
BACKGROUND: The nuclear receptors peroxisome proliferator-activated receptor γ (PPARγ) and peroxisom...
The nuclear receptor peroxisome proliferator-activated receptor-γ (PPARγ) is critically required for...
The nuclear receptor PPARα is associated with reducing adiposity, especially in the liver, where it ...
AbstractIn contrast to the well-established roles of PPARγ and PPARα in lipid metabolism, little is ...
SummaryInsulin stimulates glucose uptake through the membrane translocation of GLUT4 and GLUT1. Pero...
AbstractAdipocytes are highly specialized cells that play a central role in lipid homeostasis and th...
AbstractObesity-associated diabetes is epidemic in industrialized societies. The nuclear receptor pe...
SummaryMacrophage-mediated inflammation is a major contributor to obesity-associated insulin resista...
Adipose tissue is an important fat-storage and endocrine organ, whose dysfunction is closely associa...
SummaryThe role of the peroxisome proliferator-activated receptor-α (PPARα) in the development of in...
Objective: Adipose tissue is the primary site for lipid deposition that protects the organisms in ca...
Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a master regulator of adipose tissu...
Chronic inflammation in adipose tissue is highly associated with insulin resistance. Herein, we demo...
OBJECTIVE: Chronic activation of the nuclear factor-kappaB (NF-kappaB) in white adipose tissue leads...
Peroxisome proliferator receptor gamma (PPARγ) is a nuclear receptor first identified for its role i...
BACKGROUND: The nuclear receptors peroxisome proliferator-activated receptor γ (PPARγ) and peroxisom...
The nuclear receptor peroxisome proliferator-activated receptor-γ (PPARγ) is critically required for...
The nuclear receptor PPARα is associated with reducing adiposity, especially in the liver, where it ...
AbstractIn contrast to the well-established roles of PPARγ and PPARα in lipid metabolism, little is ...
SummaryInsulin stimulates glucose uptake through the membrane translocation of GLUT4 and GLUT1. Pero...