MutY and its human ortholog, MUTYH, repair a specific form of DNA damage: adenine mis-paired with the oxidatively modified form of deoxyguanosine, 8-oxo-7,8-dihydro-2′-deoxyguanosine. In a recent issue of Chemistry & Biology, Brinkmeyer et al. utilized mutant forms of MutY to reveal the critical residues in MutY that are required for this selectivity and specificity
AbstractBackground: Guanine residues in the genome are vulnerable to attack by free radicals and rea...
The MUTYH DNA–glycosylase is indirectly engaged in the repair of the miscoding 7,8-dihydro-8-oxo-20-...
Reactive oxygen species (ROS) constantly attack DNA. One of the best-characterized oxidative DNA les...
MutY and its human ortholog, MUTYH, repair a specific form of DNA damage: adenine mis-paired with th...
DNA is under constant bombardment from a variety of different exogenous and endogenous sources that ...
Reactive oxygen and nitrogen species (RONS) may infringe on the passing of pristine genetic informat...
The MUTYH DNA-glycosylase is indirectly engaged in the repair of the miscoding 7,8-dihydro-8-oxo-2'-...
The DNA glycosylase MUTYH (mutY homolog (Escherichia coli)) counteracts the mutagenic effects of 8-o...
The oxidized base 7,8-dihydro-8-hydroxyguanine (8-oxo-dG) is one of the most deleterious injuries in...
MUTYH is a base-excision repair glycosylase that removes adenine opposite 8-oxoguanine (OG). Variant...
Biallelic germline mutations in the base excision repair enzyme gene MUTYH lead to multiple colorect...
MutY glycosylase excises adenines misincorporated opposite the oxidatively damaged lesion, 8-oxo-7,8...
Cellular DNA is under constant threat of reactive oxygen species (ROS) produced by either endogenous...
Abstract Oxygen radicals generated through normal cellular metabolism induce a variety of types of o...
AbstractMismatch repair (MMR) corrects replication errors. It requires the MSH2, MSH6, MLH1, and PMS...
AbstractBackground: Guanine residues in the genome are vulnerable to attack by free radicals and rea...
The MUTYH DNA–glycosylase is indirectly engaged in the repair of the miscoding 7,8-dihydro-8-oxo-20-...
Reactive oxygen species (ROS) constantly attack DNA. One of the best-characterized oxidative DNA les...
MutY and its human ortholog, MUTYH, repair a specific form of DNA damage: adenine mis-paired with th...
DNA is under constant bombardment from a variety of different exogenous and endogenous sources that ...
Reactive oxygen and nitrogen species (RONS) may infringe on the passing of pristine genetic informat...
The MUTYH DNA-glycosylase is indirectly engaged in the repair of the miscoding 7,8-dihydro-8-oxo-2'-...
The DNA glycosylase MUTYH (mutY homolog (Escherichia coli)) counteracts the mutagenic effects of 8-o...
The oxidized base 7,8-dihydro-8-hydroxyguanine (8-oxo-dG) is one of the most deleterious injuries in...
MUTYH is a base-excision repair glycosylase that removes adenine opposite 8-oxoguanine (OG). Variant...
Biallelic germline mutations in the base excision repair enzyme gene MUTYH lead to multiple colorect...
MutY glycosylase excises adenines misincorporated opposite the oxidatively damaged lesion, 8-oxo-7,8...
Cellular DNA is under constant threat of reactive oxygen species (ROS) produced by either endogenous...
Abstract Oxygen radicals generated through normal cellular metabolism induce a variety of types of o...
AbstractMismatch repair (MMR) corrects replication errors. It requires the MSH2, MSH6, MLH1, and PMS...
AbstractBackground: Guanine residues in the genome are vulnerable to attack by free radicals and rea...
The MUTYH DNA–glycosylase is indirectly engaged in the repair of the miscoding 7,8-dihydro-8-oxo-20-...
Reactive oxygen species (ROS) constantly attack DNA. One of the best-characterized oxidative DNA les...
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