AbstractThe major histocompatibility complex (MHC) class I homolog MIC-A functions as a stress-inducible antigen that is recognized by a subset of γδ T cells independent of β2-microglobulin and bound peptides. Its crystal structure reveals a dramatically altered MHC class I fold, both in detail and overall domain organization. The only remnant of a peptide-binding groove is a small cavity formed as the result of disordering a large section of one of the groove-defining helices. Loss of β2-microglobulin binding is due to a restructuring of the interaction interfaces. Structural mapping of sequence variation suggests potential receptor binding sites on the underside of the platform on the side opposite of the surface recognized by αβ T cell r...
Unusually long major histocompatibility complex (MHC) class I–restricted epitopes are important in i...
The T cell receptor ( TCR) inherently has dual specificity. T cells must recognize self-antigens in ...
The crystal structure of a complex involving the D10 T cell receptor (TCR), 16-residue foreign pepti...
AbstractThe major histocompatibility complex (MHC) class I homolog MIC-A functions as a stress-induc...
MIC-A and MIC-B are distant MHC class I homologs that serve as stress-inducible Ags on epithelial an...
Mucosal-associated invariant T (MAIT) cells express a semiinvariant αβ T cell receptor (TCR) that bi...
This work investigates the mechanisms of binding of T cell receptors (TCRs) to Class I MHC-peptide c...
The Major Histocompatibility Complex (MHC) locus encodes classical MHC class I and MHC class II mole...
The cell-cell recognition events and the functional characteristics of the cell surface receptors th...
AbstractRecent crystallographic studies show that the T-cell receptor has a largely immunoglobulin-l...
The major histocompatibility complex (MHC) class I homolog, MICA, is a stress-inducible ligand for N...
T cell receptors (TCRs) recognize antigens presented by major histocompatibility complex (MHC) and M...
136 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2004.Proteins encoded by the major...
Both human and murine cytomegaloviruses (HCMV and MCMV) down-regulate expression of conventional cla...
AbstractA recent study describes direct binding between a γδ T-cell receptor and its ligand, T22, a ...
Unusually long major histocompatibility complex (MHC) class I–restricted epitopes are important in i...
The T cell receptor ( TCR) inherently has dual specificity. T cells must recognize self-antigens in ...
The crystal structure of a complex involving the D10 T cell receptor (TCR), 16-residue foreign pepti...
AbstractThe major histocompatibility complex (MHC) class I homolog MIC-A functions as a stress-induc...
MIC-A and MIC-B are distant MHC class I homologs that serve as stress-inducible Ags on epithelial an...
Mucosal-associated invariant T (MAIT) cells express a semiinvariant αβ T cell receptor (TCR) that bi...
This work investigates the mechanisms of binding of T cell receptors (TCRs) to Class I MHC-peptide c...
The Major Histocompatibility Complex (MHC) locus encodes classical MHC class I and MHC class II mole...
The cell-cell recognition events and the functional characteristics of the cell surface receptors th...
AbstractRecent crystallographic studies show that the T-cell receptor has a largely immunoglobulin-l...
The major histocompatibility complex (MHC) class I homolog, MICA, is a stress-inducible ligand for N...
T cell receptors (TCRs) recognize antigens presented by major histocompatibility complex (MHC) and M...
136 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2004.Proteins encoded by the major...
Both human and murine cytomegaloviruses (HCMV and MCMV) down-regulate expression of conventional cla...
AbstractA recent study describes direct binding between a γδ T-cell receptor and its ligand, T22, a ...
Unusually long major histocompatibility complex (MHC) class I–restricted epitopes are important in i...
The T cell receptor ( TCR) inherently has dual specificity. T cells must recognize self-antigens in ...
The crystal structure of a complex involving the D10 T cell receptor (TCR), 16-residue foreign pepti...