In response to genotoxic stress, the PIDD protein promotes apoptosis downstream of the tumor-suppressor protein p53. In this issue of Cell, Janssens et al. (2005) demonstrate that, in response to such stress, PIDD forms a nuclear complex that enhances sumoylation of NEMO. This modification is important for the activation of the antiapoptotic transcription factor NF-κB
Apoptosis is triggered by activation of initiator caspases upon complex-mediated clustering of the i...
AbstractThe transcription factor NF-κB is critical for setting the cellular sensitivities to apoptot...
Upon DNA damage, a complex called the PIDDosome is formed and either signals NF-kappaB activation an...
In response to genotoxic stress, the PIDD protein promotes apoptosis downstream of the tumor-suppres...
SummaryActivation of NF-κB following genotoxic stress allows time for DNA-damage repair and ensures ...
Abstract: Activation of NF-kappa B following genotoxic stress allows time for DNA-damage repair and ...
Activation of NF-kappaB following genotoxic stress allows time for DNA-damage repair and ensures cel...
PIDD (p53-induced protein with a death domain [DD]), together with the bipartite adapter protein RAI...
Biochemical evidence implicates the death-domain (DD) protein PIDD as a molecular switch capable of ...
The Adenovirus E1A gene sensitizes cells to genetic insults and apoptosis, most notably in response ...
tance. These data establish Mdm2 as a cleavage by enhancing p53 messenger RNA (mRNA) stability (Vilb...
P53-induced protein with a death domain (PIDD) was cloned as a death domain (DD)-containing protein ...
Caspase-2 is an evolutionarily conserved caspase, yet its biological function and cleavage targets a...
The PIDDosome, a multiprotein complex constituted of the 'p53-induced protein with a death domain (P...
Cells respond to DNA damage in a complex way and the fate of damaged cells depends on the balance be...
Apoptosis is triggered by activation of initiator caspases upon complex-mediated clustering of the i...
AbstractThe transcription factor NF-κB is critical for setting the cellular sensitivities to apoptot...
Upon DNA damage, a complex called the PIDDosome is formed and either signals NF-kappaB activation an...
In response to genotoxic stress, the PIDD protein promotes apoptosis downstream of the tumor-suppres...
SummaryActivation of NF-κB following genotoxic stress allows time for DNA-damage repair and ensures ...
Abstract: Activation of NF-kappa B following genotoxic stress allows time for DNA-damage repair and ...
Activation of NF-kappaB following genotoxic stress allows time for DNA-damage repair and ensures cel...
PIDD (p53-induced protein with a death domain [DD]), together with the bipartite adapter protein RAI...
Biochemical evidence implicates the death-domain (DD) protein PIDD as a molecular switch capable of ...
The Adenovirus E1A gene sensitizes cells to genetic insults and apoptosis, most notably in response ...
tance. These data establish Mdm2 as a cleavage by enhancing p53 messenger RNA (mRNA) stability (Vilb...
P53-induced protein with a death domain (PIDD) was cloned as a death domain (DD)-containing protein ...
Caspase-2 is an evolutionarily conserved caspase, yet its biological function and cleavage targets a...
The PIDDosome, a multiprotein complex constituted of the 'p53-induced protein with a death domain (P...
Cells respond to DNA damage in a complex way and the fate of damaged cells depends on the balance be...
Apoptosis is triggered by activation of initiator caspases upon complex-mediated clustering of the i...
AbstractThe transcription factor NF-κB is critical for setting the cellular sensitivities to apoptot...
Upon DNA damage, a complex called the PIDDosome is formed and either signals NF-kappaB activation an...
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