A variety of leptin actions require a re-examination of classic concepts of metabolic diseases. Here we present evidence for two physiologic pathways: a pathway that protects nonadipose tissues from overaccumulation of potentially toxic lipids and unrecognized paracrine interactions between α and β cells revealed by leptin’s ability to suppress diabetic hyperglucagonemia. These observations strongly point to new therapeutic possibilities for both type 1 and type 2 diabetes
SummaryLeptin has pleiotropic effects on glucose homeostasis and feeding behavior. Here, we validate...
It has long been thought that the only hormone capable of reversing the catabolic consequences of di...
Aims/hypothesis The adipose tissue-derived hormone leptin plays an important role in the maintena...
A variety of leptin actions require a re-examination of classic concepts of metabolic diseases. Here...
Type 1 diabetes is a life-long disease, with devastating consequences and no cure. While the hormone...
The hormone leptin reduces food intake and increases energy expenditure; leptin deficient rodents an...
Incidences of obesity and type 2 diabetes have risen worldwide at alarming rates. While there is an...
Leptin reverses hyperglycemia in T1D though reductions in HPA-mediated lipolysis resulting in reduce...
Leptin mimics many of the antidiabetic actions of insulin in insulin-deficient diabetes, but the mec...
Leptin is currently believed to control body composition largely, if not entirely, via hypothalamic ...
The fat derived hormone leptin plays a crucial role in the normal maintenance of body weight and ene...
By locally infecting epididymal adipocytes of obese diabetic mice with the uncoupling protein-1 tran...
AbstractIt has been established that leptin displays a number of effects on peripheral tissues. We h...
AbstractLeptin, the product of the ob gene, controls appetite through the hypothalamus and may affec...
SummaryThe hormone leptin plays a crucial role in maintenance of body weight and glucose homeostasis...
SummaryLeptin has pleiotropic effects on glucose homeostasis and feeding behavior. Here, we validate...
It has long been thought that the only hormone capable of reversing the catabolic consequences of di...
Aims/hypothesis The adipose tissue-derived hormone leptin plays an important role in the maintena...
A variety of leptin actions require a re-examination of classic concepts of metabolic diseases. Here...
Type 1 diabetes is a life-long disease, with devastating consequences and no cure. While the hormone...
The hormone leptin reduces food intake and increases energy expenditure; leptin deficient rodents an...
Incidences of obesity and type 2 diabetes have risen worldwide at alarming rates. While there is an...
Leptin reverses hyperglycemia in T1D though reductions in HPA-mediated lipolysis resulting in reduce...
Leptin mimics many of the antidiabetic actions of insulin in insulin-deficient diabetes, but the mec...
Leptin is currently believed to control body composition largely, if not entirely, via hypothalamic ...
The fat derived hormone leptin plays a crucial role in the normal maintenance of body weight and ene...
By locally infecting epididymal adipocytes of obese diabetic mice with the uncoupling protein-1 tran...
AbstractIt has been established that leptin displays a number of effects on peripheral tissues. We h...
AbstractLeptin, the product of the ob gene, controls appetite through the hypothalamus and may affec...
SummaryThe hormone leptin plays a crucial role in maintenance of body weight and glucose homeostasis...
SummaryLeptin has pleiotropic effects on glucose homeostasis and feeding behavior. Here, we validate...
It has long been thought that the only hormone capable of reversing the catabolic consequences of di...
Aims/hypothesis The adipose tissue-derived hormone leptin plays an important role in the maintena...
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