Descemet stripping with automated endothelial keratoplasty: A comparative study of outcome in patients with preexisting glaucoma

AbstractPurposeTo compare postoperative complications after Descemet stripping with automated endothelial keratoplasty (DSAEK) in patients with and without glaucoma.MethodsFor this retrospective study a series of 298 DSAEK cases performed at the Doheny Eye Institute were taken, we compared postoperative complications in eyes with glaucoma on medication (55) or with previous glaucoma surgeries (64) with a time-matched group of all other DSAEK cases (179, control).ResultsWith a mean follow-up of 1.85±1.12years, the complication rates were 12.8%, 11.1%, and 26.8% for postoperative graft detachment, graft failure, and IOP elevation, respectively. Graft detachment was an independent risk factor for graft failure (odds ratio OR=12.35, 95% confidence interval CI [5.46–27.90], P<0.001). Graft detachment was not associated with either history of glaucoma or glaucoma surgery (P>0.05). Glaucoma on medication had no increased risks of graft failure compared to normal eyes (P=0.38). However, increased risk of failure was seen in eyes with prior incisional glaucoma surgeries (OR=4.26, 95% CI [1.87–9.71], P