Vectorial nature of redox Bohr effects in bovine heart cytochrome c oxidase
- Capitanio, Nazzareno
- Capitanio, Giuseppe
- De Nitto, Emanuele
- Papa, Sergio
Publication date
September 1997
DOI Publisher
Federation of European Biochemical Societies.Abstract
AbstractThe vectorial nature of redox Bohr effects (redoxlinked pK shifts) in cytochrome c oxidase from bovine heart incorporated in liposomes has been analyzed. The Bohr effects linked to oxido-reduction of heme a and CuB display membrane vectorial asymmetry. This provides evidence for involvement of redox Bohr effects in the proton pump of the oxidase
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