AbstractThe formation of complexes between small G proteins and certain of their effectors can be facilitated by aluminum fluorides. Solution studies suggest that magnesium may be able to replace aluminum in such complexes. We have determined the crystal structure of RhoA.GDP bound to RhoGAP in the presence of Mg2+ and F− but without Al3+. The metallofluoride adopts a trigonal planar arrangement instead of the square planar structure of AlF4−. We have confirmed that these crystals contain magnesium and not aluminum by proton-induced X-ray emission spectroscopy. The structure adopted by GDP.MgF− possesses the stereochemistry and approximate charge expected for the transition state. We suggest that MgF3− may be the reagent of choice for study...
The work described in this thesis is based on the use of multinuclear NMR and protein crystallograph...
Metal fluorides (MgF3-, AIF4 - and BeF3-) have been used to mimic the transition state and ground st...
Phosphoryl transfer reactions are ubiquitous in biology, and metal fluoride TSA complexes have playe...
AbstractThe formation of complexes between small G proteins and certain of their effectors can be fa...
The formation of complexes between small G proteins and certain of their effectors can be facilitate...
In 1994, the protein structure of a transition state analogue for G1, a small G protein, heralded a ...
In 1994, the protein structure of a transition state analogue for G1, a small G protein, heralded a ...
In 1994, the protein structure of a transition state analogue for G1, a small G protein, heralded a ...
AbstractRecent three-dimensional structures of phosphoryl transfer enzymes in their aluminum fluorid...
There have been intensive efforts to try to understand the details of phosphoryl transfer reactions ...
The 1994 structure of a transition-state analogue with AlF4− and GDP complexed to G1α, a small G pro...
The 1994 structure of a transition-state analogue with AlF4− and GDP complexed to G1α, a small G pro...
The 1994 structure of a transition-state analogue with AlF4− and GDP complexed to G1α, a small G pro...
The work described in this thesis is based on the use of multinuclear NMR and protein crystallograph...
The phosphoryl group, PO3-, is the dynamic structural unit in the biological chemistry of phosphorus...
The work described in this thesis is based on the use of multinuclear NMR and protein crystallograph...
Metal fluorides (MgF3-, AIF4 - and BeF3-) have been used to mimic the transition state and ground st...
Phosphoryl transfer reactions are ubiquitous in biology, and metal fluoride TSA complexes have playe...
AbstractThe formation of complexes between small G proteins and certain of their effectors can be fa...
The formation of complexes between small G proteins and certain of their effectors can be facilitate...
In 1994, the protein structure of a transition state analogue for G1, a small G protein, heralded a ...
In 1994, the protein structure of a transition state analogue for G1, a small G protein, heralded a ...
In 1994, the protein structure of a transition state analogue for G1, a small G protein, heralded a ...
AbstractRecent three-dimensional structures of phosphoryl transfer enzymes in their aluminum fluorid...
There have been intensive efforts to try to understand the details of phosphoryl transfer reactions ...
The 1994 structure of a transition-state analogue with AlF4− and GDP complexed to G1α, a small G pro...
The 1994 structure of a transition-state analogue with AlF4− and GDP complexed to G1α, a small G pro...
The 1994 structure of a transition-state analogue with AlF4− and GDP complexed to G1α, a small G pro...
The work described in this thesis is based on the use of multinuclear NMR and protein crystallograph...
The phosphoryl group, PO3-, is the dynamic structural unit in the biological chemistry of phosphorus...
The work described in this thesis is based on the use of multinuclear NMR and protein crystallograph...
Metal fluorides (MgF3-, AIF4 - and BeF3-) have been used to mimic the transition state and ground st...
Phosphoryl transfer reactions are ubiquitous in biology, and metal fluoride TSA complexes have playe...