In vitro bioactivity of 3D Ti-mesh with bioceramic coatings in simulated body fluid

Abstract3D Ti-mesh has been coated with bioceramics under different coating conditions, such as material compositions and micro-porosity, using a dip casting method. Hydroxyapatite (HA), micro-HA particles (HAp), a bioglass (BG) and their different mixtures together with polymer additives were used to control HA-coating microstructures. Layered composites with the following coating-to-substrate designs, such as BG/Ti, HA+BG/BG/Ti and HAp+BG/BG/Ti, were fabricated. The bioactivity of these coated composites and the uncoated Ti-mesh substrate was then investigated in a simulated body fluid (SBF). The Ti-mesh substrate and BG/Ti composite did not induce biomimetic apatite deposition when they were immersed in SBF for the selected BG, a pressable dental ceramic, used in this study. After seven days in SBF, an apatite layer was formed on both HA+BG/BG/Ti and HAp+BG/BG/Ti composites. The difference is the apatite layer on the HAp+BG/BG/Ti composite was rougher and contained more micro-pores, while the apatite layer on the HA+BG/BG/Ti composite was dense and smooth. The formation of biomimetic apatite, being more bioresorbable, is favored for bone regeneration