G-CSF and CD34+ Progenitor Cells in Hematopoietic Grafts: Too Fertile for Human Cytomegalovirus

Smith et al. (2010) establish a humanized mouse model of latent host and cellular tropism of human cytomegalovirus (HCMV) infection and examine the effects of granulocyte-colony stimulating factor (GCSF) on human cytomegalovirus (HCMV) reactivation in vivo. HCMV-infected circulating CD34+ myeloid cells populate end organs such as the liver and differentiate into cells capable of supporting lytic infection