AbstractAdenine nucleotide translocase (ANT) is known as a core component of the mitochondrial permeability transition pore (MPTP) and a key player in cell death. However, its role in camptothecin (CPT)-induced apoptosis has not been examined. We showed that CPT-induced apoptosis in QGY7703 cells and down-regulated the expression of ANT3. Using ANT3 knock-out and overexpression experiments, we provide further evidence that ANT3 plays a contributive role in CPT-induced apoptosis through induction of MPTP. We speculate that the down-regulation of ANT3 upon stimulation with CPT may be part of the molecular basis underlying the mechanism of acquired resistance to CPT
This dissertation addresses the role of the adenine nucleotide translocase (ANT) protein in mitochon...
Adenine nucleotide translocase (ANT), a mitochondrial protein that facilitates the exchange of ADP a...
AbstractSeveral studies indicate that mitochondrial ATP production as well as ADP/ATP exchange acros...
AbstractAdenine nucleotide translocase (ANT) is known as a core component of the mitochondrial perme...
Mitochondrial adenine nucleotide translocase (ANT) is believed to be a component or a regulatory com...
Here, we describe the isolation of adenine nucleotide translocase-1 (ANT-1) in a screen for dominant...
Background: Adenine nucleotide translocase (ANT) is located in the inner mitochondrial membrane and ...
AbstractMitochondrial adenine nucleotide translocase 1 (ANT1), but not ANT2, can dominantly induce a...
Mitochondria have important functions in mammalian cells as the energy powerhouse and integrators of...
Adenine nucleotide translocases (ANTs) are multitask proteins involved in several aspects of cell me...
Were transfected with pcDNA-ANT1 for 12 hours, and then total or nuclear extracts were prepared and ...
Adenine nucleotide translocases (ANTs) are multitask proteins involved in several aspects of cell me...
AbstractAlthough camptothecin (CPT) has been reported to induce apoptosis in various cancer cells, t...
Mitochondria are intracellular organelles involved in ATP synthesis, apoptosis, calcium signaling, m...
AbstractThe mitochondrial adenine nucleotide translocators (Ant) are bi-functional proteins that tra...
This dissertation addresses the role of the adenine nucleotide translocase (ANT) protein in mitochon...
Adenine nucleotide translocase (ANT), a mitochondrial protein that facilitates the exchange of ADP a...
AbstractSeveral studies indicate that mitochondrial ATP production as well as ADP/ATP exchange acros...
AbstractAdenine nucleotide translocase (ANT) is known as a core component of the mitochondrial perme...
Mitochondrial adenine nucleotide translocase (ANT) is believed to be a component or a regulatory com...
Here, we describe the isolation of adenine nucleotide translocase-1 (ANT-1) in a screen for dominant...
Background: Adenine nucleotide translocase (ANT) is located in the inner mitochondrial membrane and ...
AbstractMitochondrial adenine nucleotide translocase 1 (ANT1), but not ANT2, can dominantly induce a...
Mitochondria have important functions in mammalian cells as the energy powerhouse and integrators of...
Adenine nucleotide translocases (ANTs) are multitask proteins involved in several aspects of cell me...
Were transfected with pcDNA-ANT1 for 12 hours, and then total or nuclear extracts were prepared and ...
Adenine nucleotide translocases (ANTs) are multitask proteins involved in several aspects of cell me...
AbstractAlthough camptothecin (CPT) has been reported to induce apoptosis in various cancer cells, t...
Mitochondria are intracellular organelles involved in ATP synthesis, apoptosis, calcium signaling, m...
AbstractThe mitochondrial adenine nucleotide translocators (Ant) are bi-functional proteins that tra...
This dissertation addresses the role of the adenine nucleotide translocase (ANT) protein in mitochon...
Adenine nucleotide translocase (ANT), a mitochondrial protein that facilitates the exchange of ADP a...
AbstractSeveral studies indicate that mitochondrial ATP production as well as ADP/ATP exchange acros...