Chromatin modifications are important for embryonic stem cell (ESC) pluripotency, but their functions in adult stem cells are less clear. In this issue of Cell Stem Cell, Lien et al. (2011) delineate histone methylation patterns in hair follicle stem cells and show that these marks differ from those of ESCs
Polycomb Repressive Complex 2 (PRC2) catalyzes histone H3 lysine 27 tri-methylation (H3K27me3), an e...
SummaryWe mapped Polycomb-associated H3K27 trimethylation (H3K27me3) and Trithorax-associated H3K4 t...
BACKGROUND: The therapeutic use of multipotent stem cells depends on their differentiation potential...
Chromatin modifications are important for embryonic stem cell (ESC) pluripotency, but their function...
SummaryHuman embryonic stem cells (hESCs) share an identical genome with lineage-committed cells, ye...
SummaryUsing mouse skin, where bountiful reservoirs of synchronized hair follicle stem cells (HF-SCs...
The pluripotent state of embryonic stem cells (ESCs) provides a unique perspective on regulatory pro...
SummaryThe molecular mechanisms underlying pluripotency and lineage specification from embryonic ste...
SummaryDifferentiation of human embryonic stem cells (hESCs) provides a unique opportunity to study ...
Significance : Derived from the inner cell mass of the preimplantation embryo, embryonic stem cells ...
Embryonic stem (ES) cells can replicate indefinitely while retaining the capacity to differentiate i...
Mammalian development requires the creation of hundreds of cell types, each with distinct patterns o...
A core network of genes maintaining pluripotency has been at least partially defined. How the geneti...
SummaryHuman embryonic stem cells (hESCs) expressing pluripotency markers are assumed to possess equ...
Embryonic stem cells (ESCs) are defined by two essential features—pluripotency and self-renewal—whos...
Polycomb Repressive Complex 2 (PRC2) catalyzes histone H3 lysine 27 tri-methylation (H3K27me3), an e...
SummaryWe mapped Polycomb-associated H3K27 trimethylation (H3K27me3) and Trithorax-associated H3K4 t...
BACKGROUND: The therapeutic use of multipotent stem cells depends on their differentiation potential...
Chromatin modifications are important for embryonic stem cell (ESC) pluripotency, but their function...
SummaryHuman embryonic stem cells (hESCs) share an identical genome with lineage-committed cells, ye...
SummaryUsing mouse skin, where bountiful reservoirs of synchronized hair follicle stem cells (HF-SCs...
The pluripotent state of embryonic stem cells (ESCs) provides a unique perspective on regulatory pro...
SummaryThe molecular mechanisms underlying pluripotency and lineage specification from embryonic ste...
SummaryDifferentiation of human embryonic stem cells (hESCs) provides a unique opportunity to study ...
Significance : Derived from the inner cell mass of the preimplantation embryo, embryonic stem cells ...
Embryonic stem (ES) cells can replicate indefinitely while retaining the capacity to differentiate i...
Mammalian development requires the creation of hundreds of cell types, each with distinct patterns o...
A core network of genes maintaining pluripotency has been at least partially defined. How the geneti...
SummaryHuman embryonic stem cells (hESCs) expressing pluripotency markers are assumed to possess equ...
Embryonic stem cells (ESCs) are defined by two essential features—pluripotency and self-renewal—whos...
Polycomb Repressive Complex 2 (PRC2) catalyzes histone H3 lysine 27 tri-methylation (H3K27me3), an e...
SummaryWe mapped Polycomb-associated H3K27 trimethylation (H3K27me3) and Trithorax-associated H3K4 t...
BACKGROUND: The therapeutic use of multipotent stem cells depends on their differentiation potential...