Autophosphorylation of calmodulin kinase II: functional aspects
- Bronstein, J.M.
- Farber, D.B.
- Wasterlain, C.G.
Publication date
February 1986
DOI Publisher
Published by Elsevier B.V. ISSN
0014-5793 Citation count (estimate)
9Abstract
AbstractAutophosphorylation of purified calmodulin kinase II dramatically inhibited protein kinase activity and enhanced substrate selectivity. Inhibition was observed over a wide range of calmodulin concentrations but calmodulin binding was unaffected. Autophosphorylation of calmodulin kinase II may be a mechanism for limiting phosphorylation to physiological substrates and terminating some of calcium's actions in synaptic events
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