The cognitive effects of oxcarbazepine versus carbamazepine or valproate in newly diagnosed children with partial seizures
- Donati, Filippo
- Gobbi, Giuseppe
- Campistol, Jaume
- Rapatz, Guenter
- Daehler, Maja
- Sturm, Yvonne
- Aldenkamp, Albert P.
DOIAbstract
SummaryObjectiveTo investigate the effect of oxcarbazepine against standard antiepileptic drug therapy (carbamazepine and valproate) on cognitive function in children and adolescents (aged 6 to <17 years) with newly diagnosed partial seizures.MethodsA multicentre, open-label, randomised, active-control, three-arm, parallel-group, 6-month study. The primary cognitive variable, the Computerized Visual Searching Task (CVST), assessed mental information processing speed and attention. Secondary variables included additional tests assessing psychomotor speed, alertness, memory and learning, and non-verbal intelligence.ResultsOf 112 patients randomised, 99 completed the study. The dropout rate was 11.6%; 13 patients discontinued due to adverse ev...
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