Renal ischemia–reperfusion injury is a major cause of acute kidney injury. We previously found that renal A1 adenosine receptor (A1AR) activation attenuated multiple cell death pathways including necrosis, apoptosis, and inflammation. Here, we tested whether induction of cytoprotective sphingosine kinase (SK)-1 and sphingosine-1-phosphate (S1P) synthesis might be the mechanism of protection. A selective A1AR agonist (CCPA) increased the synthesis of S1P and selectively induced SK1 in mouse kidney and HK-2 cells. This agonist failed to protect SK1-knockout but protected SK2-knockout mice against renal ischemia–reperfusion injury indicating a critical role of SK1 in A1AR-mediated renal protection. Inhibition of SK prevented A1AR-mediated defe...
Acute kidney injury (AKI) induced by ischaemia and reperfusion (I/R) injury is a common and severe c...
BACKGROUND. Acute renal failure from ischemia significantly contributes to morbidity and mortali...
Sphingosine kinases (SKs) are key enzymes regulating the production of sphingosine-1-phosphate (S1P)...
Renal ischemia–reperfusion injury is a major cause of acute kidney injury. We previously found that ...
Genetic deletion of the adenosine A1 receptor (A1AR) increased renal injury following ischemia–reper...
The roles of sphingosine kinases SK1 and SK2 in ischemia–reperfusion injury have not been fully eluc...
Sphingosine-1-phosphate (S1P), produced by sphingosine kinase 1 (SphK1) or kinase 2 (SphK2), mediate...
Sphingosine-1-phospate is a lipid mediator that has been implicated in protection from acute kidney ...
The pathogenesis of renal ischemia/reperfusion (I/R) injury involves activating several signal trans...
We have shown that A1 adenosine receptors (A1ARs) are cytoprotective against renal tubular necrosis ...
The role for the endothelial sphingosine-1-phosphate 1 receptor (S1P1R) in acute kidney injury (AKI)...
We previously showed that activation of the A1 adenosine receptor protected the kidney against ische...
T cells are thought to be involved in the pathogenesis of renal ischemia–reperfusion injury (IRI); h...
Because of its highly bioactive properties sphingosine 1-phosphate (S1P) is an attractive target for...
The major sphingolipid metabolite, sphingosine-1-phosphate (S1P), has important biological functions...
Acute kidney injury (AKI) induced by ischaemia and reperfusion (I/R) injury is a common and severe c...
BACKGROUND. Acute renal failure from ischemia significantly contributes to morbidity and mortali...
Sphingosine kinases (SKs) are key enzymes regulating the production of sphingosine-1-phosphate (S1P)...
Renal ischemia–reperfusion injury is a major cause of acute kidney injury. We previously found that ...
Genetic deletion of the adenosine A1 receptor (A1AR) increased renal injury following ischemia–reper...
The roles of sphingosine kinases SK1 and SK2 in ischemia–reperfusion injury have not been fully eluc...
Sphingosine-1-phosphate (S1P), produced by sphingosine kinase 1 (SphK1) or kinase 2 (SphK2), mediate...
Sphingosine-1-phospate is a lipid mediator that has been implicated in protection from acute kidney ...
The pathogenesis of renal ischemia/reperfusion (I/R) injury involves activating several signal trans...
We have shown that A1 adenosine receptors (A1ARs) are cytoprotective against renal tubular necrosis ...
The role for the endothelial sphingosine-1-phosphate 1 receptor (S1P1R) in acute kidney injury (AKI)...
We previously showed that activation of the A1 adenosine receptor protected the kidney against ische...
T cells are thought to be involved in the pathogenesis of renal ischemia–reperfusion injury (IRI); h...
Because of its highly bioactive properties sphingosine 1-phosphate (S1P) is an attractive target for...
The major sphingolipid metabolite, sphingosine-1-phosphate (S1P), has important biological functions...
Acute kidney injury (AKI) induced by ischaemia and reperfusion (I/R) injury is a common and severe c...
BACKGROUND. Acute renal failure from ischemia significantly contributes to morbidity and mortali...
Sphingosine kinases (SKs) are key enzymes regulating the production of sphingosine-1-phosphate (S1P)...