A New Twist in Smad Signaling

Signaling by members of the TGFβ family is much dependent on the common-mediator Smad4, which forms transcriptionally active complexes with all receptor-activated Smads (R-Smads). New findings demonstrate that transcriptional intermediary factor 1γ (TIF1γ) also can bind to R-Smads, as an alternative to Smad4, and mediate different transcriptional effects