SummaryDuring development of the retinocollicular projection in mouse, retinal axons initially overshoot their future termination zones (TZs) in the superior colliculus (SC). The formation of TZs is initiated by interstitial branching at topographically appropriate positions. Ephrin-As are expressed in a decreasing posterior-to-anterior gradient in the SC, and they suppress branching posterior to future TZs. Here we investigate the role of an EphA7 gradient in the SC, which has the reverse orientation to the ephrin-A gradient. We find that in EphA7 mutant mice the retinocollicular map is disrupted, with nasal and temporal axons forming additional or extended TZs, respectively. In vitro, retinal axons are repelled from growing on EphA7-conta...
Genetic hardwiring during brain development provides computational architectures for innate neuronal...
AbstractEphrin-As have been implicated as topographic mapping labels in the retinotectal system, but...
AbstractRepulsion plays a fundamental role in the establishment of a topographic map of the chick re...
SummaryDuring development of the retinocollicular projection in mouse, retinal axons initially overs...
SummaryEphrinAs and EphAs play critical roles during topographic map formation in the retinocollicul...
AbstractTopographic maps are a fundamental feature of sensory representations in nervous systems. Th...
AbstractEphrin-A5 (AL-1/RAGS), a ligand for Eph receptor tyrosine kinases, repels retinal axons in v...
SummaryEngrailed transcription factors regulate the expression of guidance cues that pattern retinal...
AbstractRetinal axons project to their central targets along two orthogonal topographic axes, anteri...
Retinal ganglion cells (RGCs) project axons from their cell bodies in the eye to targets in the supe...
AbstractEphrin-As act as retinal topographic mapping labels, but the molecular basis for two key asp...
BACKGROUND: In wild-type mice, axons of retinal ganglion cells establish topographically precise pro...
AbstractVisual connections to the mammalian forebrain are known to be patterned by neural activity, ...
AbstractEphrin-B and EphB are distributed in matching dorsoventral gradients in the embryonic Xenopu...
AbstractIn the retinotectal projection, the Eph receptor tyrosine kinase ligands ephrinA2 and ephrin...
Genetic hardwiring during brain development provides computational architectures for innate neuronal...
AbstractEphrin-As have been implicated as topographic mapping labels in the retinotectal system, but...
AbstractRepulsion plays a fundamental role in the establishment of a topographic map of the chick re...
SummaryDuring development of the retinocollicular projection in mouse, retinal axons initially overs...
SummaryEphrinAs and EphAs play critical roles during topographic map formation in the retinocollicul...
AbstractTopographic maps are a fundamental feature of sensory representations in nervous systems. Th...
AbstractEphrin-A5 (AL-1/RAGS), a ligand for Eph receptor tyrosine kinases, repels retinal axons in v...
SummaryEngrailed transcription factors regulate the expression of guidance cues that pattern retinal...
AbstractRetinal axons project to their central targets along two orthogonal topographic axes, anteri...
Retinal ganglion cells (RGCs) project axons from their cell bodies in the eye to targets in the supe...
AbstractEphrin-As act as retinal topographic mapping labels, but the molecular basis for two key asp...
BACKGROUND: In wild-type mice, axons of retinal ganglion cells establish topographically precise pro...
AbstractVisual connections to the mammalian forebrain are known to be patterned by neural activity, ...
AbstractEphrin-B and EphB are distributed in matching dorsoventral gradients in the embryonic Xenopu...
AbstractIn the retinotectal projection, the Eph receptor tyrosine kinase ligands ephrinA2 and ephrin...
Genetic hardwiring during brain development provides computational architectures for innate neuronal...
AbstractEphrin-As have been implicated as topographic mapping labels in the retinotectal system, but...
AbstractRepulsion plays a fundamental role in the establishment of a topographic map of the chick re...