AbstractTranscription factor PU.1 is required for the development of lymphoid and myeloid progenitors during fetal hematopoiesis. By generating chimeric animals using PU.1−/− ES cells or PU.1−/− hematopoietic progenitors, we demonstrate that PU.1 functions in an exclusively cell-autonomous manner to regulate the development of the lymphoid–myeloid system. Multipotential lymphoid–myeloid progenitors (AA4.1+, Lin−) are significantly reduced in PU.1−/− embryos and fail to differentiate into B lymphoid or myeloid cells in vitro. These results suggest that the lymphoid and myeloid lineages develop in the fetal liver from a common hematopoietic progenitor not shared with erythrocytes and megakaryocytes. Finally, the Ikaros gene is expressed in PU...
Objective. The Ets-family transcription factor PU.1 is expressed specifically in the hematopoietic s...
PU.1 is a hematopoietic-specific transcrip-tional activator that is absolutely required for the diff...
Generation of myeloid and lymphoid cells from progenitors involves dynamic changes in transcription ...
AbstractTranscription factor PU.1 is required for the development of lymphoid and myeloid progenitor...
PU.1 is an Ets family transcription factor that is essential for fetal liver hematopoiesis. We have ...
© 2013 Dr. Swee Heng PangPU.1 is a central regulator of foetal haematopoiesis. Conditional knockout ...
PU.1 is a member of the ETS family of transcription factors and is required for the development of m...
AbstractThe essential hematopoietic transcription factor PU.1 is expressed in multipotent thymic pre...
AbstractDevelopment of the lymphoid system is dependent on the Ets family transcription factor PU.1....
Although the transcription factor PU.1 is essential for fetal lymphomyelopoiesis, we unexpectedly fo...
The transcription factor PU.1 is required for the development of mature myeloid and lymphoid cells. ...
The transcription factor PU.1 is required for the development of mature myeloid and lymphoid cells. ...
AbstractWe have previously shown using gene targeting that PU.1 is essential for the development of ...
SummaryA hierarchical hematopoietic development with myeloid versus lymphoid bifurcation has been pr...
PU.1 is an ETS-family transcription factor that plays a broad range of roles in hematopoiesis. A dir...
Objective. The Ets-family transcription factor PU.1 is expressed specifically in the hematopoietic s...
PU.1 is a hematopoietic-specific transcrip-tional activator that is absolutely required for the diff...
Generation of myeloid and lymphoid cells from progenitors involves dynamic changes in transcription ...
AbstractTranscription factor PU.1 is required for the development of lymphoid and myeloid progenitor...
PU.1 is an Ets family transcription factor that is essential for fetal liver hematopoiesis. We have ...
© 2013 Dr. Swee Heng PangPU.1 is a central regulator of foetal haematopoiesis. Conditional knockout ...
PU.1 is a member of the ETS family of transcription factors and is required for the development of m...
AbstractThe essential hematopoietic transcription factor PU.1 is expressed in multipotent thymic pre...
AbstractDevelopment of the lymphoid system is dependent on the Ets family transcription factor PU.1....
Although the transcription factor PU.1 is essential for fetal lymphomyelopoiesis, we unexpectedly fo...
The transcription factor PU.1 is required for the development of mature myeloid and lymphoid cells. ...
The transcription factor PU.1 is required for the development of mature myeloid and lymphoid cells. ...
AbstractWe have previously shown using gene targeting that PU.1 is essential for the development of ...
SummaryA hierarchical hematopoietic development with myeloid versus lymphoid bifurcation has been pr...
PU.1 is an ETS-family transcription factor that plays a broad range of roles in hematopoiesis. A dir...
Objective. The Ets-family transcription factor PU.1 is expressed specifically in the hematopoietic s...
PU.1 is a hematopoietic-specific transcrip-tional activator that is absolutely required for the diff...
Generation of myeloid and lymphoid cells from progenitors involves dynamic changes in transcription ...