SummaryHistocompatibility in the basal chordate Botryllus schlosseri is controlled by the polymorphisms of a single gene: the fuhc. A polymorphic candidate receptor (fester) appeared to play roles in both initiating the reaction and discriminating between fuhc alleles. Here we report the characterization of a related protein, uncle fester. uncle fester is not polymorphic, and although coexpressed with fester, has different functional properties. Loss-of-function studies demonstrate that uncle fester was required for incompatible reactions but has no role in interactions between compatible individuals. Furthermore, stimulation with monoclonal antibodies could initiate a rejection phenotype on a single colony, and in both assays the severity ...
Understanding the mechanisms that sustain immunological nonreactivity is essential for maintaining t...
Oren M, Paz G, Douek J, et al. 'Rejected' vs. 'rejecting' transcriptomes in allogeneic challenged co...
Allorecognition, i.e., the ability of intraspecific nonself recognition is widely distributed among ...
SummaryHistocompatibility in the primitive chordate, Botryllus schlosseri, is controlled by a single...
Abstract Background Allorecognition, the ability of an organism to distinguish self from non-self, o...
SummaryAlloimmune specificity and histocompatibility, driven by genetic polymorphism, are ancient de...
SummaryColonial marine invertebrates, such as sponges, corals, bryozoans, and ascidians, often live ...
Nearly all colonial marine invertebrates are capable of allorecognition — the ability to distinguish...
In Botryllus schlosseri, a highly polymorphic allorecognition system limits the potential for vascul...
<div><p>The basal chordate <i>Botryllus schlosseri</i> undergoes a natural transplantation reaction ...
SummaryIn the colonial tunicate Botryllus schlosseri, a co-dominant trait determines the capacity of...
SummarySessile colonial invertebrates—animals such as sponges, corals, bryozoans, and ascidians—can ...
The basal chordate Botryllus schlosseri undergoes a natural transplantation reaction governed by a s...
In the compound ascidian Botryllus schlosseri, allorecognition manifests primarily as colony specifi...
SYNOPSIS. Colonial basal metazoans often encounter members of their own species as they grow on hard...
Understanding the mechanisms that sustain immunological nonreactivity is essential for maintaining t...
Oren M, Paz G, Douek J, et al. 'Rejected' vs. 'rejecting' transcriptomes in allogeneic challenged co...
Allorecognition, i.e., the ability of intraspecific nonself recognition is widely distributed among ...
SummaryHistocompatibility in the primitive chordate, Botryllus schlosseri, is controlled by a single...
Abstract Background Allorecognition, the ability of an organism to distinguish self from non-self, o...
SummaryAlloimmune specificity and histocompatibility, driven by genetic polymorphism, are ancient de...
SummaryColonial marine invertebrates, such as sponges, corals, bryozoans, and ascidians, often live ...
Nearly all colonial marine invertebrates are capable of allorecognition — the ability to distinguish...
In Botryllus schlosseri, a highly polymorphic allorecognition system limits the potential for vascul...
<div><p>The basal chordate <i>Botryllus schlosseri</i> undergoes a natural transplantation reaction ...
SummaryIn the colonial tunicate Botryllus schlosseri, a co-dominant trait determines the capacity of...
SummarySessile colonial invertebrates—animals such as sponges, corals, bryozoans, and ascidians—can ...
The basal chordate Botryllus schlosseri undergoes a natural transplantation reaction governed by a s...
In the compound ascidian Botryllus schlosseri, allorecognition manifests primarily as colony specifi...
SYNOPSIS. Colonial basal metazoans often encounter members of their own species as they grow on hard...
Understanding the mechanisms that sustain immunological nonreactivity is essential for maintaining t...
Oren M, Paz G, Douek J, et al. 'Rejected' vs. 'rejecting' transcriptomes in allogeneic challenged co...
Allorecognition, i.e., the ability of intraspecific nonself recognition is widely distributed among ...