Although much is known about the genes that promote metastasis, few suppressors of metastasis have been found. Adorno et al. (2009) now identify p63 as a potent suppressor of metastasis and uncover an intricate mechanism for the inactivation of metastasis in cancer cells in response to transforming growth factor β
Understanding drivers for metastasis in human cancer is important for potential development of thera...
The development of solid tumors is regulated by dynamic interactions between evolving neoplastic cel...
The NR4A1–NR4A3 (Nur77, Nurr1, and Nor-1) subfamily of nuclear receptors is a group of immediate ear...
Although much is known about the genes that promote metastasis, few suppressors of metastasis have b...
Nuclear corepressor 1 (NCoR) associates with nuclear receptors and other transcription factors lead...
Inducible transcriptional programs mediate the regulation of key biological processes and organismal...
Cancer is one of the leading causes of death and disease in the world. Considerable resources are sp...
AbstractNumerous lines of investigation suggest that nuclear factor NF-κB, a proinflammatory transcr...
SummaryTGFβ ligands act as tumor suppressors in early stage tumors but are paradoxically diverted in...
Switching between elongated and rounded modes of movement allows invasive tumor cells to adapt to va...
AbstractChronic inflammation in tumor microenvironment plays an important role at different stages o...
The abilities of NF-κB to promote cell proliferation, suppress apoptosis, promote cell migration, an...
Summary: NF-κB is considered a major contributor to tumor development, but how this factor functions...
Nur77, an orphan member of the nuclear receptor superfamily, plays critical roles in inflammation an...
Primary cancer cell dissemination is a key event during the metastatic cascade, but context-specific...
Understanding drivers for metastasis in human cancer is important for potential development of thera...
The development of solid tumors is regulated by dynamic interactions between evolving neoplastic cel...
The NR4A1–NR4A3 (Nur77, Nurr1, and Nor-1) subfamily of nuclear receptors is a group of immediate ear...
Although much is known about the genes that promote metastasis, few suppressors of metastasis have b...
Nuclear corepressor 1 (NCoR) associates with nuclear receptors and other transcription factors lead...
Inducible transcriptional programs mediate the regulation of key biological processes and organismal...
Cancer is one of the leading causes of death and disease in the world. Considerable resources are sp...
AbstractNumerous lines of investigation suggest that nuclear factor NF-κB, a proinflammatory transcr...
SummaryTGFβ ligands act as tumor suppressors in early stage tumors but are paradoxically diverted in...
Switching between elongated and rounded modes of movement allows invasive tumor cells to adapt to va...
AbstractChronic inflammation in tumor microenvironment plays an important role at different stages o...
The abilities of NF-κB to promote cell proliferation, suppress apoptosis, promote cell migration, an...
Summary: NF-κB is considered a major contributor to tumor development, but how this factor functions...
Nur77, an orphan member of the nuclear receptor superfamily, plays critical roles in inflammation an...
Primary cancer cell dissemination is a key event during the metastatic cascade, but context-specific...
Understanding drivers for metastasis in human cancer is important for potential development of thera...
The development of solid tumors is regulated by dynamic interactions between evolving neoplastic cel...
The NR4A1–NR4A3 (Nur77, Nurr1, and Nor-1) subfamily of nuclear receptors is a group of immediate ear...
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