Proteostatic Hotspots in Amyloid Fibrils Protect Us from Neurodegeneration

Alzheimer’s disease remains a formidable challenge for therapeutic management. In a recent report in Nature Structural and Molecular Biology, Cohen et al. (2015) present intriguing results showing that “designer” molecular chaperones may hold the key to an evolutionarily conserved program for management of toxic oligomer species contributing to brain pathobiology