Latent TGF-β binding protein-3 (LTBP-3) requires binding to TGF-β for secretion
- Chen, Yan
- Dabovic, Branka
- Annes, Justin P
- Rifkin, Daniel B
Publication date
April 2002
DOI Publisher
Federation of European Biochemical Societies. Published by Elsevier B.V. ISSN
0014-5793Abstract
AbstractLatent transforming growth factor-β (TGF-β) binding protein (LTBP)-1, which is easily secreted, has been shown to enhance the secretion of TGF-β. Here we show that another member of the LTBP family, LTBP-3, is not secreted by several cell types, but secretion occurs after coexpression with TGF-β. The secretion of LTBP-3 requires complexing of LTBP-3 with Cys33 of the TGF-β propeptide
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