SummarySignaling events that regulate central nervous system (CNS) angiogenesis and blood-brain barrier (BBB) formation are only beginning to be elucidated. By evaluating the gene expression profile of mouse vasculature, we identified DR6/TNFRSF21 and TROY/TNFRSF19 as regulators of CNS-specific angiogenesis in both zebrafish and mice. Furthermore, these two death receptors interact both genetically and physically and are required for vascular endothelial growth factor (VEGF)-mediated JNK activation and subsequent human brain endothelial sprouting in vitro. Increasing beta-catenin levels in brain endothelium upregulate DR6 and TROY, indicating that these death receptors are downstream target genes of Wnt/beta-catenin signaling, which has bee...
Canonical Wnt signaling is crucial for vascularization of the central nervous system and blood-brain...
The BMP pathway regulates developmental processes including angiogenesis, yet its signaling outputs ...
The circumventricular organs (CVOs) in the central nervous system (CNS) lack a vascular blood-brain ...
SummarySignaling events that regulate central nervous system (CNS) angiogenesis and blood-brain barr...
Vascularization of the vertebrate brain takes place during embryonic development from a preformed pe...
The blood-brain barrier (BBB) is essential for maintaining homeostasis within the central nervous sy...
Objective- The Wnt/beta-catenin pathway orchestrates development of the blood-brain barrier, but the...
TGFβ signalling in endothelial cells is important for angiogenesis in early embryonic development, b...
Objective- The Wnt/β-catenin pathway orchestrates development of the blood-brain barrier, but the do...
Objective- The Wnt/β-catenin pathway orchestrates development of the blood-brain barrier, but the do...
The blood–brain barrier (BBB) is confined to the endothelium of brain capillaries and is indispensab...
The acquisition of brain vascular properties, like tight junctions and pericytes, to form the blood-...
The circumventricular organs (CVOs) in the central nervous system (CNS) lack a vascular blood-brain ...
Rationale: The microvasculature of the central nervous system includes the blood-brain barrier (BBB)...
UnlabelledAs neural structures grow in size and increase metabolic demand, the CNS vasculature under...
Canonical Wnt signaling is crucial for vascularization of the central nervous system and blood-brain...
The BMP pathway regulates developmental processes including angiogenesis, yet its signaling outputs ...
The circumventricular organs (CVOs) in the central nervous system (CNS) lack a vascular blood-brain ...
SummarySignaling events that regulate central nervous system (CNS) angiogenesis and blood-brain barr...
Vascularization of the vertebrate brain takes place during embryonic development from a preformed pe...
The blood-brain barrier (BBB) is essential for maintaining homeostasis within the central nervous sy...
Objective- The Wnt/beta-catenin pathway orchestrates development of the blood-brain barrier, but the...
TGFβ signalling in endothelial cells is important for angiogenesis in early embryonic development, b...
Objective- The Wnt/β-catenin pathway orchestrates development of the blood-brain barrier, but the do...
Objective- The Wnt/β-catenin pathway orchestrates development of the blood-brain barrier, but the do...
The blood–brain barrier (BBB) is confined to the endothelium of brain capillaries and is indispensab...
The acquisition of brain vascular properties, like tight junctions and pericytes, to form the blood-...
The circumventricular organs (CVOs) in the central nervous system (CNS) lack a vascular blood-brain ...
Rationale: The microvasculature of the central nervous system includes the blood-brain barrier (BBB)...
UnlabelledAs neural structures grow in size and increase metabolic demand, the CNS vasculature under...
Canonical Wnt signaling is crucial for vascularization of the central nervous system and blood-brain...
The BMP pathway regulates developmental processes including angiogenesis, yet its signaling outputs ...
The circumventricular organs (CVOs) in the central nervous system (CNS) lack a vascular blood-brain ...