Predictive factors for evaluation of response to fluticasone propionate/salmeterol combination in severe COPD
- Tonnel, Andre-Bernard
- Tillie-Leblond, Isabelle
- Attali, Valerie
- Bavelele, Zola
- Lagrange, Olivier
DOIAbstract
SummaryBackgroundThe predictive factors for treatment response in patients with severe chronic obstructive pulmonary disease (COPD) are unknown. We investigated predictive factors for response to fluticasone propionate/salmeterol (FSC) in severe COPD patients.MethodsThis prospective, open-label, non-comparative study included 921 adult patients with severe COPD (baseline forced expiratory volume in 1 s (FEV1) <50% of predicted), a history of repeated exacerbations, and symptoms despite bronchodilator treatment. FSC (500 μg/50 μg) was delivered via an inhaler, twice a day, for 12 weeks. The primary efficacy endpoint was the response rate for inspiratory capacity (IC), FEV1, or quality of life (QoL), assessed with the Saint George’s respirato...
Add to ORKG