The transcription factor hypoxia-inducible factor 1 (HIF1) facilitates the induction of enzymes necessary for anaerobic glycolysis. Luo et al. (2011) now identify pyruvate kinase (PK)-M2 as an intriguing new interacting partner for HIF1, revealing a potential mechanism for the Warburg effect, an elevation in aerobic glycolytic metabolism frequently observed in cancer
The phenomenon of aerobic glycolysis observed in cancer cells has remained unexplained. In the May 2...
<div><p>Cancer can be envisioned as a metabolic disease driven by pressure selection and intercellul...
SummaryMany cancer cells are characterized by increased glycolysis and decreased respiration, even u...
The transcription factor hypoxia-inducible factor 1 (HIF1) facilitates the induction of enzymes nece...
SummaryThe pyruvate kinase isoforms PKM1 and PKM2 are alternatively spliced products of the PKM2 gen...
Hypoxic cells induce glycolytic enzymes; this HIF-1-mediated metabolic adaptation increases glucose ...
The maintenance of oxygen homeostasis is critical for survival, and the master regulator of this pro...
SummaryActivation of glycolytic genes by HIF-1 is considered critical for metabolic adaptation to hy...
AbstractMetastatic tumors generally exhibit aerobic glycolysis (the Warburg effect). The advent of [...
Most tumor cells take up more glucose than normal cells but metabolize glucose via glycolysis even i...
Normal cells produce adenosine 5′-triphosphate (ATP) mainly through mitochondrial oxidative phosphor...
SummaryThe HIF-1 transcription factor drives hypoxic gene expression changes that are thought to be ...
In the early twentieth century, Otto Heinrich Warburg described an elevated rate of glycolysis occur...
AbstractCancer cells are characterized by high glycolytic rates to support energy regeneration and a...
Normal Glycolytic Enzyme Activity is Critical for Hypoxia Inducible Factor-1α Activity and Provides ...
The phenomenon of aerobic glycolysis observed in cancer cells has remained unexplained. In the May 2...
<div><p>Cancer can be envisioned as a metabolic disease driven by pressure selection and intercellul...
SummaryMany cancer cells are characterized by increased glycolysis and decreased respiration, even u...
The transcription factor hypoxia-inducible factor 1 (HIF1) facilitates the induction of enzymes nece...
SummaryThe pyruvate kinase isoforms PKM1 and PKM2 are alternatively spliced products of the PKM2 gen...
Hypoxic cells induce glycolytic enzymes; this HIF-1-mediated metabolic adaptation increases glucose ...
The maintenance of oxygen homeostasis is critical for survival, and the master regulator of this pro...
SummaryActivation of glycolytic genes by HIF-1 is considered critical for metabolic adaptation to hy...
AbstractMetastatic tumors generally exhibit aerobic glycolysis (the Warburg effect). The advent of [...
Most tumor cells take up more glucose than normal cells but metabolize glucose via glycolysis even i...
Normal cells produce adenosine 5′-triphosphate (ATP) mainly through mitochondrial oxidative phosphor...
SummaryThe HIF-1 transcription factor drives hypoxic gene expression changes that are thought to be ...
In the early twentieth century, Otto Heinrich Warburg described an elevated rate of glycolysis occur...
AbstractCancer cells are characterized by high glycolytic rates to support energy regeneration and a...
Normal Glycolytic Enzyme Activity is Critical for Hypoxia Inducible Factor-1α Activity and Provides ...
The phenomenon of aerobic glycolysis observed in cancer cells has remained unexplained. In the May 2...
<div><p>Cancer can be envisioned as a metabolic disease driven by pressure selection and intercellul...
SummaryMany cancer cells are characterized by increased glycolysis and decreased respiration, even u...
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