Cholesterol levels in mammalian cells are controlled by an intricate mechanism in which the transcription factor SREBP plays a key role. Work in this issue (Radhakrishnan et al., 2008) employing direct measurement of endoplasmic reticulum cholesterol levels offers insights into the “switch” that controls this system with surprising precision
SummaryThe liver contributes to glucose homeostasis by promoting either storage or production of glu...
SummaryElevated plasma cholesterol levels are considered responsible for excess cardiovascular morbi...
Calorie restriction (CR) has been reported to increase SIRT1 protein levels in mice, rats, and human...
Cholesterol levels in mammalian cells are controlled by an intricate mechanism in which the transcri...
SummaryDyslipidemia and atherosclerosis are associated with reduced insulin sensitivity and diabetes...
Cholesterol synthesis is regulated by the transcription factor sterol regulatory element binding pro...
AbstractSREBPs are transcriptional activators central to cholesterol homeostasis. Recent work has sh...
AbstractTranscriptional regulation and membrane traffic have traditionally been quite separate field...
SummarySterol regulatory element-binding proteins (SREBPs) activate genes involved in the synthesis ...
SummaryThis paper describes a convergent mechanism for the feedback control of cholesterol synthesis...
The SIRT1 deacetylase inhibits fat synthesis and stimulates fat oxidation in response to fasting, bu...
The NAD-dependent deacetylase SIRT1 regulates lipid and carbohydrate metabolism and has been shown t...
SummaryThe NAD+-dependent protein deacetylase SIRT6 regulates genome stability, cancer, and lifespan...
Sterol regulatory element-binding protein (SREBP) transcription factors regulate cellular lipogenesi...
SummarySterol regulatory element-binding proteins (SREBPs) are key transcriptional regulators of lip...
SummaryThe liver contributes to glucose homeostasis by promoting either storage or production of glu...
SummaryElevated plasma cholesterol levels are considered responsible for excess cardiovascular morbi...
Calorie restriction (CR) has been reported to increase SIRT1 protein levels in mice, rats, and human...
Cholesterol levels in mammalian cells are controlled by an intricate mechanism in which the transcri...
SummaryDyslipidemia and atherosclerosis are associated with reduced insulin sensitivity and diabetes...
Cholesterol synthesis is regulated by the transcription factor sterol regulatory element binding pro...
AbstractSREBPs are transcriptional activators central to cholesterol homeostasis. Recent work has sh...
AbstractTranscriptional regulation and membrane traffic have traditionally been quite separate field...
SummarySterol regulatory element-binding proteins (SREBPs) activate genes involved in the synthesis ...
SummaryThis paper describes a convergent mechanism for the feedback control of cholesterol synthesis...
The SIRT1 deacetylase inhibits fat synthesis and stimulates fat oxidation in response to fasting, bu...
The NAD-dependent deacetylase SIRT1 regulates lipid and carbohydrate metabolism and has been shown t...
SummaryThe NAD+-dependent protein deacetylase SIRT6 regulates genome stability, cancer, and lifespan...
Sterol regulatory element-binding protein (SREBP) transcription factors regulate cellular lipogenesi...
SummarySterol regulatory element-binding proteins (SREBPs) are key transcriptional regulators of lip...
SummaryThe liver contributes to glucose homeostasis by promoting either storage or production of glu...
SummaryElevated plasma cholesterol levels are considered responsible for excess cardiovascular morbi...
Calorie restriction (CR) has been reported to increase SIRT1 protein levels in mice, rats, and human...
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