ACCUMULATION OF CYCLIC ADENOSINE 3', 5'-MONOPHOSPHATE IN ADULT AND NEWBORN MOUSE SKIN: RESPONSES TO ISCHEMIA AND ISOPROTERENOL

Levels of cyclic adenosine 3', 5' -monophosphate in adult mouse skin pieces were rapidly increased on incubation at 37°C, or on exposure to isoproterenol. Accumulation of the cyclic nucleotide under both conditions was greatly decreased in newborn mouse skin, or in adult skin treated with the tumor promotor 12-0-tetradecanoyl-phorbol-13-acetate