SummaryX chromosome inactivation (XCI) is a dynamically regulated developmental process with inactivation and reactivation accompanying the loss and gain of pluripotency, respectively. A functional relationship between pluripotency and lack of XCI has been suggested, whereby pluripotency transcription factors repress the master regulator of XCI, the noncoding transcript Xist, by binding to its first intron (intron 1). To test this model, we have generated intron 1 mutant embryonic stem cells (ESCs) and two independent mouse models. We found that Xist’s repression in ESCs, its transcriptional upregulation upon differentiation, and its silencing upon reprogramming to pluripotency are not dependent on intron 1. Although we observed subtle effe...
X chromosome inactivation, the transcriptional inactivation of one X chromosome in somatic cells of ...
Despite decades of biochemical, proteomic and genetic characterizations of the Xist longnon-coding R...
X chromosome inactivation (XCI) is the mammalian mechanism that compensates for the difference in ge...
SummaryX chromosome inactivation (XCI) is a dynamically regulated developmental process with inactiv...
X chromosome inactivation (XCI) is a dynamically regulated developmental process with inactivation a...
During mouse embryogenesis, reversion of imprinted X chromosome inactivation in the pluripotent inne...
In female mammals, X chromosome inactivation (XCI) is a key process in the control of gene dosage co...
BACKGROUND: Expression of Xist, the master regulator of X chromosome inactivation, is extinguished i...
SummaryXX female mammals undergo transcriptional silencing of most genes on one of their two X-chrom...
AbstractDevelopmental regulation of the mouse Xist gene at the onset of X chromosome inactivation is...
X inactivation is the mammalian method for X-chromosome dosage compensation, but some features of th...
X-chromosome inactivation is evolution's answer to compensate for the gonosomal discrepancy between ...
To ensure dosage compensation for X-linked genes between the sexes, one X chromosome is silenced dur...
X-chromosome inactivation is a mechanism that has evolved in mammalian females allowing dosage comp...
X chromosome inactivation (XCI) is the mammalian mechanism that compensates for the difference in ge...
X chromosome inactivation, the transcriptional inactivation of one X chromosome in somatic cells of ...
Despite decades of biochemical, proteomic and genetic characterizations of the Xist longnon-coding R...
X chromosome inactivation (XCI) is the mammalian mechanism that compensates for the difference in ge...
SummaryX chromosome inactivation (XCI) is a dynamically regulated developmental process with inactiv...
X chromosome inactivation (XCI) is a dynamically regulated developmental process with inactivation a...
During mouse embryogenesis, reversion of imprinted X chromosome inactivation in the pluripotent inne...
In female mammals, X chromosome inactivation (XCI) is a key process in the control of gene dosage co...
BACKGROUND: Expression of Xist, the master regulator of X chromosome inactivation, is extinguished i...
SummaryXX female mammals undergo transcriptional silencing of most genes on one of their two X-chrom...
AbstractDevelopmental regulation of the mouse Xist gene at the onset of X chromosome inactivation is...
X inactivation is the mammalian method for X-chromosome dosage compensation, but some features of th...
X-chromosome inactivation is evolution's answer to compensate for the gonosomal discrepancy between ...
To ensure dosage compensation for X-linked genes between the sexes, one X chromosome is silenced dur...
X-chromosome inactivation is a mechanism that has evolved in mammalian females allowing dosage comp...
X chromosome inactivation (XCI) is the mammalian mechanism that compensates for the difference in ge...
X chromosome inactivation, the transcriptional inactivation of one X chromosome in somatic cells of ...
Despite decades of biochemical, proteomic and genetic characterizations of the Xist longnon-coding R...
X chromosome inactivation (XCI) is the mammalian mechanism that compensates for the difference in ge...