AbstractP-glycoprotein (P-gp), an active efflux pump of antitumor drugs, is strongly expressed in endothelial cells of the blood brain barrier (BBB). Two proteins (155 and 190 kDa) were detected by Western blot analysis of beef and rat capillaries with the monoclonal antibody (MAb) C219. In order to characterize the nature of these proteins, their profile of solubilization by different detergents was established and compared with that of P-gp from the CHRC5 tumoral cell line. The 155 kDa protein (p155) of capillaries and the P-gp of CHRC5 cells were well solubilized by deoxycholate and Elugent, whereas the 190 kDa protein (p190) was only solubilized by sodium dodecylsulfate (SDS). Both proteins have different patterns of extraction by Trito...
Over 1 billion people worldwide suffer from some type of central nervous system (CNS) disorder (WHO,...
International audienceTo determine whether compounds are able to reach the neural microenvironment, ...
© the authors; Chemotherapy is an essential part of anticancer treatment. However, the overexpressio...
AbstractP-glycoprotein (P-gp), an active efflux pump of antitumor drugs, is strongly expressed in en...
Malignant brain tumor is a lethal disease with currently available treatment options having a limite...
Abstract Background In vitro models based on brain capillary endothelial cells (BCECs) are among the...
The P-glycoprotein efflux system located on the apical membrane of brain capillary endothelial cells...
Expression of breast cancer resistance protein (Bcrp) at the blood-brain barrier (BBB) has been reve...
P-glycoprotein (Pgp; ABCB1/MDR1) is a major efflux transporter at the blood-brain barrier (BBB), res...
This thesis reveals additional insights in the functional behavior of P-glycoprotein in the human bl...
AbstractP-Glycoprotein (P-gp) is a 180-kDa membrane-bound transporter which can confer the multi-dru...
P-glycoprotein (Pgp; ABCB1/MDR1) is a major efflux transporter at the blood-brain barrier (BBB), res...
AbstractIn vivo expression of P-glycoprotein in isolated rat brain microvessels is compared with tha...
P-glycoprotein (P-gp) is an ATP-dependent efflux transporter located at the blood–brain barrier (BB...
P-glycoprotein (P-gp) is a transmembrane drug efflux pump encoded by the MDR-1 gene in humans. Most ...
Over 1 billion people worldwide suffer from some type of central nervous system (CNS) disorder (WHO,...
International audienceTo determine whether compounds are able to reach the neural microenvironment, ...
© the authors; Chemotherapy is an essential part of anticancer treatment. However, the overexpressio...
AbstractP-glycoprotein (P-gp), an active efflux pump of antitumor drugs, is strongly expressed in en...
Malignant brain tumor is a lethal disease with currently available treatment options having a limite...
Abstract Background In vitro models based on brain capillary endothelial cells (BCECs) are among the...
The P-glycoprotein efflux system located on the apical membrane of brain capillary endothelial cells...
Expression of breast cancer resistance protein (Bcrp) at the blood-brain barrier (BBB) has been reve...
P-glycoprotein (Pgp; ABCB1/MDR1) is a major efflux transporter at the blood-brain barrier (BBB), res...
This thesis reveals additional insights in the functional behavior of P-glycoprotein in the human bl...
AbstractP-Glycoprotein (P-gp) is a 180-kDa membrane-bound transporter which can confer the multi-dru...
P-glycoprotein (Pgp; ABCB1/MDR1) is a major efflux transporter at the blood-brain barrier (BBB), res...
AbstractIn vivo expression of P-glycoprotein in isolated rat brain microvessels is compared with tha...
P-glycoprotein (P-gp) is an ATP-dependent efflux transporter located at the blood–brain barrier (BB...
P-glycoprotein (P-gp) is a transmembrane drug efflux pump encoded by the MDR-1 gene in humans. Most ...
Over 1 billion people worldwide suffer from some type of central nervous system (CNS) disorder (WHO,...
International audienceTo determine whether compounds are able to reach the neural microenvironment, ...
© the authors; Chemotherapy is an essential part of anticancer treatment. However, the overexpressio...