SummaryWe genetically dissect the contribution of the most prominent downstream translational components of mTOR signaling toward Akt-driven lymphomagenesis. While phosphorylation of rpS6 is dispensable for cancer formation, 4EBP-eIF4E exerts significant control over cap-dependent translation, cell growth, cancer initiation, and progression. This effect is mediated at least in part through 4EBP-dependent control of Mcl-1 expression, a key antiapoptotic protein. By using an active site inhibitor of mTOR, PP242, we show a marked therapeutic response in rapamycin-resistant tumors. The therapeutic benefit of PP242 is mediated through inhibition of mTORC1-dependent 4EBP-eIF4E hyperactivation. Thus, the 4EBP-eIF4E axis downstream of mTOR is a dru...
Throughout the years, research into signalling pathways involved in cancer progression has led to ma...
The mTORC1 inhibitors, rapamycin and its analogs, are known to show only modest antitumor activity i...
The mammalian target of rapamycin (mTOR) plays an important role in the regulation of protein transl...
SummaryWe genetically dissect the contribution of the most prominent downstream translational compon...
The AKT-mTOR pathway harbors several known and putative oncogenes and tumor suppressors. In a phenot...
Although it was first observed nearly a century ago that transformed cells are marked by enlarged nu...
Activation of the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway is a frequent occurrenc...
SummaryThe signal transduction pathway wherein mTOR regulates cellular growth and proliferation is a...
Targeting the translational machinery has emerged as a promising therapeutic option for cancer treat...
There is currently a wealth of information regarding the mutations that contribute to cancer develop...
The mechanistic target of rapamycin (mTOR) is a kinase whose activation is associated with poor prog...
Review International audienceThere is currently a high level of interest in signalling through the m...
: The mechanistic/mammalian target of rapamycin (mTOR) is the crucial hub of signalling pathways tha...
In this issue of Cancer Cell, She et al. show that in cancer cells a protein called 4E-BP1 is a key ...
There is currently a high level of interest in signalling through the mammalian target of rapamycin ...
Throughout the years, research into signalling pathways involved in cancer progression has led to ma...
The mTORC1 inhibitors, rapamycin and its analogs, are known to show only modest antitumor activity i...
The mammalian target of rapamycin (mTOR) plays an important role in the regulation of protein transl...
SummaryWe genetically dissect the contribution of the most prominent downstream translational compon...
The AKT-mTOR pathway harbors several known and putative oncogenes and tumor suppressors. In a phenot...
Although it was first observed nearly a century ago that transformed cells are marked by enlarged nu...
Activation of the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway is a frequent occurrenc...
SummaryThe signal transduction pathway wherein mTOR regulates cellular growth and proliferation is a...
Targeting the translational machinery has emerged as a promising therapeutic option for cancer treat...
There is currently a wealth of information regarding the mutations that contribute to cancer develop...
The mechanistic target of rapamycin (mTOR) is a kinase whose activation is associated with poor prog...
Review International audienceThere is currently a high level of interest in signalling through the m...
: The mechanistic/mammalian target of rapamycin (mTOR) is the crucial hub of signalling pathways tha...
In this issue of Cancer Cell, She et al. show that in cancer cells a protein called 4E-BP1 is a key ...
There is currently a high level of interest in signalling through the mammalian target of rapamycin ...
Throughout the years, research into signalling pathways involved in cancer progression has led to ma...
The mTORC1 inhibitors, rapamycin and its analogs, are known to show only modest antitumor activity i...
The mammalian target of rapamycin (mTOR) plays an important role in the regulation of protein transl...