Caffeine in the Treatment of Pain

SummaryBackground and objectivesCaffeine is a widely used substance with effects on several systems, presenting characteristic of pharmacokinetic and pharmacodynamic which cause interactions with several drugs. This study's objective is to review the effects caused by caffeine.ContentThis review assesses the caffeine pharmacology, its action mechanisms, indications, contraindications, doses, interactions and adverse effects.ConclusionsThere are insufficient double-blind randomized controlled studies that assess the analgesic effect of caffeine on several painful syndromes. Patients presenting chronic pain need caution when it comes to tolerance development, abstinence and drug interaction from chronic caffeine use