Clathrin: An Amazing Multifunctional Dreamcoat?

SummaryInternalization of cargo by clathrin-mediated endocytosis has been studied extensively. In this issue of Cell Host & Microbe, Cossart and colleagues report that a variety of pathogens induce the recruitment of clathrin and other endocytic proteins to sites of pathogen interaction with the cell surface. This recruitment is followed by actin rearrangements in the host cell necessary for the uptake or stable attachment of the pathogen at the cell surface