AbstractBackground: Human immunodeficiency virus type 1 (HIV-1) is the causative agent of AIDS and the subject of intense study. The immature HIV-1 particle is traditionally described as having a well ordered, icosahedral structure made up of uncleaved Gag protein surrounded by a lipid bilayer containing envelope proteins. Expression of the Gag protein in eukaryotic cells leads to the budding of membranous virus-like particles (VLPs).Results: We have used cryo-electron microscopy of VLPs from insect cells and lightly fixed, immature HIV-1 particles from human lymphocytes to determine their organization. Both types of particle were heterogeneous in size, varying in diameter from 1200–2600 Å. Larger particles appeared to be broken into semisp...
HIV-1 buds form infected cells in an immature, non-infectious form. Maturation into an infectious vi...
HIV-1 buds form infected cells in an immature, non-infectious form. Maturation into an infectious vi...
SummaryInfectious HIV particles contain a characteristic cone-shaped core encasing the viral RNA and...
While the structures of nearly every HIV-1 protein are known in atomic detail from X-ray crystallogr...
To better characterize the assembly of the HIV-1 core, we have used electron cryo-tomography (ECT) t...
The structure of immature and mature HIV-1 particles has been analyzed in detail by cryo electron mi...
The structure of immature and mature HIV-1 particles has been analyzed in detail by cryo electron mi...
The assembly of HIV-1 is mediated by oligomerization of the major structural polyprotein, Gag, into ...
SummaryCurrent models of HIV-1 morphogenesis hold that newly synthesized viral Gag polyproteins traf...
Retrovirus assembly proceeds via multimerisation of the major structural protein, Gag, into a tightl...
The RNA genome of retroviruses is encased within a protein capsid. To gather insight into the assemb...
Human immunodeficiency virus type 1 (HIV-1) assembly proceeds in two stages. First, the 55 kilodalto...
During retrovirus particle maturation, the assembled Gag polyprotein is cleaved by the viral proteas...
The major structural elements of retroviruses are contained in a single polyprotein, Gag, which in h...
Human immunodeficiency virus type 1 (HIV-1) is an enveloped lentivirus from the family Retroviridae ...
HIV-1 buds form infected cells in an immature, non-infectious form. Maturation into an infectious vi...
HIV-1 buds form infected cells in an immature, non-infectious form. Maturation into an infectious vi...
SummaryInfectious HIV particles contain a characteristic cone-shaped core encasing the viral RNA and...
While the structures of nearly every HIV-1 protein are known in atomic detail from X-ray crystallogr...
To better characterize the assembly of the HIV-1 core, we have used electron cryo-tomography (ECT) t...
The structure of immature and mature HIV-1 particles has been analyzed in detail by cryo electron mi...
The structure of immature and mature HIV-1 particles has been analyzed in detail by cryo electron mi...
The assembly of HIV-1 is mediated by oligomerization of the major structural polyprotein, Gag, into ...
SummaryCurrent models of HIV-1 morphogenesis hold that newly synthesized viral Gag polyproteins traf...
Retrovirus assembly proceeds via multimerisation of the major structural protein, Gag, into a tightl...
The RNA genome of retroviruses is encased within a protein capsid. To gather insight into the assemb...
Human immunodeficiency virus type 1 (HIV-1) assembly proceeds in two stages. First, the 55 kilodalto...
During retrovirus particle maturation, the assembled Gag polyprotein is cleaved by the viral proteas...
The major structural elements of retroviruses are contained in a single polyprotein, Gag, which in h...
Human immunodeficiency virus type 1 (HIV-1) is an enveloped lentivirus from the family Retroviridae ...
HIV-1 buds form infected cells in an immature, non-infectious form. Maturation into an infectious vi...
HIV-1 buds form infected cells in an immature, non-infectious form. Maturation into an infectious vi...
SummaryInfectious HIV particles contain a characteristic cone-shaped core encasing the viral RNA and...