The Reparative Function of Cardiomyocytes in the Infarcted Myocardium

Effective repair of the infarcted heart requires spatial containment of the inflammatory reaction within the infarcted area. A recently published study demonstrates that in the pro-inflammatory environment of the infarct border zone, surviving cardiomyocytes restrain inflammation by activating a Reg3β-dependent cascade that recruits reparative macrophages and promotes neutrophil clearance