AbstractWe report a type of synaptic modulation that involves retrograde signaling from postsynaptic metabotropic glutamate receptors (mGluRs) to presynaptic cannabinoid receptors. Activation of mGluR subtype 1 (mGluR1) expressed in cerebellar Purkinje cells (PCs) reduced neurotransmitter release from excitatory climbing fibers. This required activation of G proteins but not Ca2+ elevation in postsynaptic PCs. This effect was occluded by a cannabinoid agonist and totally abolished by cannabinoid antagonists. Depolarization-induced Ca2+ transients in PCs also caused cannabinoid receptor-mediated presynaptic inhibition. Thus, endocannabinoid production in PCs can be initiated by two distinct stimuli. Activation of mGluR1 by repetitive stimula...
<div><p>Cannabinoid receptors are the most abundant G protein-coupled receptors in the brain and the...
AbstractNeuronal excitability and long-term synaptic plasticity at excitatory synapses are criticall...
AbstractAt inhibitory synapses on a cerebellar Purkinje neuron, the depolarization caused by heteros...
AbstractWe report a type of synaptic modulation that involves retrograde signaling from postsynaptic...
We investigated the mechanisms by which activation of group I metabotropic glutamate receptors (mGlu...
AbstractBrief depolarization of cerebellar Purkinje cells was found to inhibit parallel fiber and cl...
金沢大学医薬保健研究域保健学系Endocannabinoids mediate retrograde signaling and modulate synaptic transmission in v...
Postsynaptic release of endocannabinoids can inhibit presynaptic neurotransmitter release on short a...
AbstractEndogenous cannabinoids are considered to function as diffusible and short-lived modulators ...
SummaryThe long-term depression (LTD) of parallel fiber (PF) synapses onto Purkinje cells plays a ce...
Depolarization of cerebellar Purkinje neurons transiently sup-presses IPSCs through a process known ...
Endocannabinoids are key intercellular signaling molecules in the brain, but the physiological regul...
Psychological and physiological effects of marijuana are caused by binding of its active component (...
Depolarisation-induced suppression of inhibition (DSI) is a form of short-term synaptic plasticity a...
Cannabinoid receptors are the most abundant G protein-coupled receptors in the brain and they mediat...
<div><p>Cannabinoid receptors are the most abundant G protein-coupled receptors in the brain and the...
AbstractNeuronal excitability and long-term synaptic plasticity at excitatory synapses are criticall...
AbstractAt inhibitory synapses on a cerebellar Purkinje neuron, the depolarization caused by heteros...
AbstractWe report a type of synaptic modulation that involves retrograde signaling from postsynaptic...
We investigated the mechanisms by which activation of group I metabotropic glutamate receptors (mGlu...
AbstractBrief depolarization of cerebellar Purkinje cells was found to inhibit parallel fiber and cl...
金沢大学医薬保健研究域保健学系Endocannabinoids mediate retrograde signaling and modulate synaptic transmission in v...
Postsynaptic release of endocannabinoids can inhibit presynaptic neurotransmitter release on short a...
AbstractEndogenous cannabinoids are considered to function as diffusible and short-lived modulators ...
SummaryThe long-term depression (LTD) of parallel fiber (PF) synapses onto Purkinje cells plays a ce...
Depolarization of cerebellar Purkinje neurons transiently sup-presses IPSCs through a process known ...
Endocannabinoids are key intercellular signaling molecules in the brain, but the physiological regul...
Psychological and physiological effects of marijuana are caused by binding of its active component (...
Depolarisation-induced suppression of inhibition (DSI) is a form of short-term synaptic plasticity a...
Cannabinoid receptors are the most abundant G protein-coupled receptors in the brain and they mediat...
<div><p>Cannabinoid receptors are the most abundant G protein-coupled receptors in the brain and the...
AbstractNeuronal excitability and long-term synaptic plasticity at excitatory synapses are criticall...
AbstractAt inhibitory synapses on a cerebellar Purkinje neuron, the depolarization caused by heteros...