Safety of sputum induction in moderate-to-severe chronic obstructive pulmonary disease
- SUTHERLAND, E.RAND
- AK, J.P.
- LANGMACK, E.L.
- SILKOFF, P.E.
- MARTIN, R.J.
DOIAbstract
AbstractThis retrospective study was designed to evaluate the safety and efficacy of a bronchoprotective sputum induction protocol in moderate to severe chronic obstructive pulmonary disease (COPD). Forty-two adults with COPD (FEV1 = 51.7±3.2% predicted (mean±SEM)) underwent sputum induction using a protocol designed to minimize hypertonic saline-induced bronchoconstriction. Hypertonic (3%) saline was used for subjects with FEV1 ≥50%, and normal (0.9%) saline was used for subjects with FEV1 <50%. Primary outcomes were change in peak flow, FEV1 and oxygen saturation. Mean decline in peak flow during sputum induction was 13.2±2.1%. FEV1 fell by 11.4±2.3%, an absolute fall of 0.14±0.03 l. Oxygen saturation did not change. A fall in peak flow o...
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