Alterations in cortical thickness development in preterm-born individuals: Implications for high-order cognitive functions

Nam, Kie Woo
Castellanos, Nazareth
Simmons, Andrew
Froudist-Walsh, Seán
Allin, Matthew P.
Walshe, Muriel
Murray, Robin M.
Evans, Alan
Muehlboeck, J-Sebastian
Nosarti, Chiara

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Publication date

July 2015

DOI

10.1016/j.neuroimage.2015.04.015

Publisher

The Authors. Published by Elsevier Inc.

ISSN

1053-8119

Citation count (estimate)

Abstract

AbstractVery preterm birth (gestational age <33weeks) is associated with alterations in cortical thickness and with neuropsychological/behavioural impairments. Here we studied cortical thickness in very preterm born individuals and controls in mid-adolescence (mean age 15years) and beginning of adulthood (mean age 20years), as well as longitudinal changes between the two time points. Using univariate approaches, we showed both increases and decreases in cortical thickness in very preterm born individuals compared to controls. Specifically (1) very preterm born adolescents displayed extensive areas of greater cortical thickness, especially in occipitotemporal and prefrontal cortices, differences which decreased substantially by early adultho...