Random Genetic Drift Determines the Level of Mutant mtDNA in Human Primary Oocytes
- Brown, D.T.
- Samuels, D.C.
- Michael, E.M.
- Turnbull, D.M.
- Chinnery, P.F.
Publication date
February 2001
DOI Publisher
The American Society of Human Genetics. Published by Elsevier Inc. ISSN
0002-9297 Citation count (estimate)
119Abstract
We measured the proportion of mutant mtDNA (mutation load) in 82 primary oocytes from a woman who harbored the A3243G mtDNA mutation. The frequency distribution of mutation load indicates that random drift is the principal mechanism that determines the level of mutant mtDNA within individual oocytes
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