Squamous cell carcinoma arising from an epidermal cyst of the scrotum

AbstractWe present an 83-year-old man with squamous cell carcinoma in the lining of an epidermal cyst that had been in his scrotum for more than 23 years. The patient presented with a discharge from the lesion, and received oral antibiotics, followed by wide excision of the cyst. We found the excised cyst wall was uneven. Serial sections of the thickened part showed squamous cell carcinoma. The patient had an uneventful recovery after surgery. Malignant transformation in an epidermal cyst is rare,with only a few such cases reported in the English literature