In this issue of Cancer Cell, Huang et al. report that preventing exit from mitosis provides a very efficient strategy for killing cells. Although this is not an unexpected finding, it nevertheless provides a novel conceptual framework for augmenting the antimitotic strategies currently under development for fighting cancer
There is an unmet need for new antimitotic drug combinations that target cancer-specific vulnerabili...
One of the most exciting developments in recent cancer treatment has been the move away from crude c...
Genotoxic stress such as ionizing radiation halts entry into mitosis by activation of the G2 DNA dam...
SummaryCurrent antimitotics work by perturbing spindle assembly, which activates the spindle assembl...
SummaryDrugs targeting the mitotic spindle are used extensively during chemotherapy, but surprisingl...
Cell fate in response to an aberrant mitosis is governed by two competing networks: the spindle asse...
Many of the current antitumor therapeutic strategies are based on the perturbation of the cell cycle...
Targeting the mitotic machinery using anti-mitotic drugs for elimination of cancer cells is a centur...
AbstractA checkpoint surveying the entry into mitosis responds to defects in spindle microtubule ass...
Many of the current antitumor therapeutic strategies are based on the perturbation of the cell cycle...
As cancer cells are actively dividing, mitosis is one of the most common targets for anticancer chem...
Targeting the mitotic machinery using anti-mitotic drugs for elimination of cancer cells is a centur...
Targeting the mitotic pathways of rapidly proliferating tumor cells has been an effective strategy i...
The mitotic spindle assembly checkpoint (SCP) is a signal transduction pathway that ensures proper c...
Mitotic cell death (MCD) is commonly used interchangeably with mitotic catastrophe. However, these e...
There is an unmet need for new antimitotic drug combinations that target cancer-specific vulnerabili...
One of the most exciting developments in recent cancer treatment has been the move away from crude c...
Genotoxic stress such as ionizing radiation halts entry into mitosis by activation of the G2 DNA dam...
SummaryCurrent antimitotics work by perturbing spindle assembly, which activates the spindle assembl...
SummaryDrugs targeting the mitotic spindle are used extensively during chemotherapy, but surprisingl...
Cell fate in response to an aberrant mitosis is governed by two competing networks: the spindle asse...
Many of the current antitumor therapeutic strategies are based on the perturbation of the cell cycle...
Targeting the mitotic machinery using anti-mitotic drugs for elimination of cancer cells is a centur...
AbstractA checkpoint surveying the entry into mitosis responds to defects in spindle microtubule ass...
Many of the current antitumor therapeutic strategies are based on the perturbation of the cell cycle...
As cancer cells are actively dividing, mitosis is one of the most common targets for anticancer chem...
Targeting the mitotic machinery using anti-mitotic drugs for elimination of cancer cells is a centur...
Targeting the mitotic pathways of rapidly proliferating tumor cells has been an effective strategy i...
The mitotic spindle assembly checkpoint (SCP) is a signal transduction pathway that ensures proper c...
Mitotic cell death (MCD) is commonly used interchangeably with mitotic catastrophe. However, these e...
There is an unmet need for new antimitotic drug combinations that target cancer-specific vulnerabili...
One of the most exciting developments in recent cancer treatment has been the move away from crude c...
Genotoxic stress such as ionizing radiation halts entry into mitosis by activation of the G2 DNA dam...