During neoplastic transformation, cells can promote their own growth by activating proto-oncogenes. Reporting in Cell, Iliopoulos et al. (2009) now show that in certain cell types, a transient oncogenic signal is sufficient to induce neoplastic transformation and to maintain it through a positive feedback loop driven by the inflammatory cytokine interleukin-6
The evolution of Acute Myeloid Leukemia (AML) is a complex process characterized by the stepwise acc...
AbstractThe chromosomal translocation t(7;9)(q34;q34.3) in human T cell acute lymphoblastic leukemia...
How cells generate a single axis of polarity for mating, division, and movement is unknown. In this ...
<div><p>Recently, a molecular pathway linking inflammation to cell transformation has been discovere...
Recently, a molecular pathway linking inflammation to cell transformation has been discovered. This ...
SummaryInflammation is linked clinically and epidemiologically to cancer, and NF-κB appears to play ...
Data accessibility: All the code and data used in this paper are available at the GitHub repository ...
Recombination at stalled replication forks is regulated at an early stage by sumoylation. In this is...
Molecular alterations in genes involved in DNA mismatch repair (MMR) promote cancer initiation and f...
The dynamics of tumor cell populations is hotly debated: do populations derive hierarchically from a...
The initiation of DNA replication is a complex, multistep process with important implications for ge...
Identifying the cancer cells-of-origin is of great interest, as it holds the potential to elucidate ...
Mutations are a critical driver of cancer initiation. While extensive studies have focused on exposu...
Maintenance of genomic stability is critical for tumour suppression. Deregulation of the DNA replica...
Genome instability occurs early in the development of most cancers. Bester et al. now provide eviden...
The evolution of Acute Myeloid Leukemia (AML) is a complex process characterized by the stepwise acc...
AbstractThe chromosomal translocation t(7;9)(q34;q34.3) in human T cell acute lymphoblastic leukemia...
How cells generate a single axis of polarity for mating, division, and movement is unknown. In this ...
<div><p>Recently, a molecular pathway linking inflammation to cell transformation has been discovere...
Recently, a molecular pathway linking inflammation to cell transformation has been discovered. This ...
SummaryInflammation is linked clinically and epidemiologically to cancer, and NF-κB appears to play ...
Data accessibility: All the code and data used in this paper are available at the GitHub repository ...
Recombination at stalled replication forks is regulated at an early stage by sumoylation. In this is...
Molecular alterations in genes involved in DNA mismatch repair (MMR) promote cancer initiation and f...
The dynamics of tumor cell populations is hotly debated: do populations derive hierarchically from a...
The initiation of DNA replication is a complex, multistep process with important implications for ge...
Identifying the cancer cells-of-origin is of great interest, as it holds the potential to elucidate ...
Mutations are a critical driver of cancer initiation. While extensive studies have focused on exposu...
Maintenance of genomic stability is critical for tumour suppression. Deregulation of the DNA replica...
Genome instability occurs early in the development of most cancers. Bester et al. now provide eviden...
The evolution of Acute Myeloid Leukemia (AML) is a complex process characterized by the stepwise acc...
AbstractThe chromosomal translocation t(7;9)(q34;q34.3) in human T cell acute lymphoblastic leukemia...
How cells generate a single axis of polarity for mating, division, and movement is unknown. In this ...
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