The pyruvate dehydrogenase complex (PDC) catalyzes the conversion of pyruvate into acetyl-CoA, a critical step in metabolism. Sutendra et al. now demonstrate that PDC can translocate from the mitochondria to the nucleus to provide acetyl-CoA necessary for histone acetylation, suggesting a new pathway for mitochondrial-nuclear communication
The mechanisms by which mitochondrial metabolism supports cancer anabolism remain unclear. Here, we ...
Abstract The scope and variety of the metabolic intermediates from the mitochondrial tricarboxylic a...
The metabolism of CHO cells is characterized by a low efficiency of glucose metabolism, resulting in...
The pyruvate dehydrogenase complex (PDC) catalyzes the conversion of pyruvate into acetyl-CoA, a cri...
The pyruvate dehydrogenase complex (PDC) catalyzes the conversion of pyruvate into acetyl-CoA, a cri...
SummaryDNA transcription, replication, and repair are regulated by histone acetylation, a process th...
The mitochondrial pyruvate carrier (MPC) is essential for several major pathways of carbohydrate, fa...
In the mitochondrion, pyruvate is converted into acetyl-CoA by the py-ruvate dehydrogenase (PDH) com...
The majority of polypeptides in the mitochondrion are nuclear encoded and post-translationally trans...
AbstractPyruvate promotes hyperpolarization of the inner mitochondrial membrane. However, in isolate...
The mechanisms by which mitochondrial metabolism supports cancer anabolism remain unclear. Here, we ...
Pyruvate sits at an important metabolic crossroads of intermediary metabolism. As a product of glyco...
Nucleic acid and histone modifications critically depend on the tricarboxylic acid (TCA) cycle for s...
Recent studies point out the link between altered mitochondrial metabolism and cancer, and detailed ...
Mitochondrial dysfunction is a hallmark of metabolic diseases such as obesity, type 2 diabetes melli...
The mechanisms by which mitochondrial metabolism supports cancer anabolism remain unclear. Here, we ...
Abstract The scope and variety of the metabolic intermediates from the mitochondrial tricarboxylic a...
The metabolism of CHO cells is characterized by a low efficiency of glucose metabolism, resulting in...
The pyruvate dehydrogenase complex (PDC) catalyzes the conversion of pyruvate into acetyl-CoA, a cri...
The pyruvate dehydrogenase complex (PDC) catalyzes the conversion of pyruvate into acetyl-CoA, a cri...
SummaryDNA transcription, replication, and repair are regulated by histone acetylation, a process th...
The mitochondrial pyruvate carrier (MPC) is essential for several major pathways of carbohydrate, fa...
In the mitochondrion, pyruvate is converted into acetyl-CoA by the py-ruvate dehydrogenase (PDH) com...
The majority of polypeptides in the mitochondrion are nuclear encoded and post-translationally trans...
AbstractPyruvate promotes hyperpolarization of the inner mitochondrial membrane. However, in isolate...
The mechanisms by which mitochondrial metabolism supports cancer anabolism remain unclear. Here, we ...
Pyruvate sits at an important metabolic crossroads of intermediary metabolism. As a product of glyco...
Nucleic acid and histone modifications critically depend on the tricarboxylic acid (TCA) cycle for s...
Recent studies point out the link between altered mitochondrial metabolism and cancer, and detailed ...
Mitochondrial dysfunction is a hallmark of metabolic diseases such as obesity, type 2 diabetes melli...
The mechanisms by which mitochondrial metabolism supports cancer anabolism remain unclear. Here, we ...
Abstract The scope and variety of the metabolic intermediates from the mitochondrial tricarboxylic a...
The metabolism of CHO cells is characterized by a low efficiency of glucose metabolism, resulting in...
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