Reduced inflammatory and muscle damage biomarkers following oral supplementation with bioavailable curcumin

AbstractBackgroundExercise-Induced Muscle Damage (EIMD) and delayed onset muscle soreness (DOMS) impact subsequent training sessions and activities of daily living (ADL) even in active individuals. In sedentary or diseased individuals, EIMD and DOMS may be even more pronounced and present even in the absence of structured exercise.MethodsThe purpose of this study was to determine the effects of oral curcumin supplementation (Longvida® 400mg/days) on muscle & ADL soreness, creatine kinase (CK), and inflammatory cytokines (TNF-α, IL-6, IL-8, IL-10) following EMID (eccentric-only dual-leg press exercise). Subjects (N=28) were randomly assigned to either curcumin (400mg/day) or placebo (rice flour) and supplemented 2days before to 4days after EMID. Blood samples were collected prior to (PRE), and 1, 2, 3, and 4days after EIMD to measure CK and inflammatory cytokines. Data were analyzed by ANOVA with P