Head and neck carcinogenesis: impact of MTHFD1 G1958A polymorphism

Batista da Silva, Lidia Maria Rebolho
da Silva, Jéssika Nunes Gomes
Silva Galbiatti, Ana Lívia
Succi, Maysa
Ruiz, Mariangela Torreglosa
Raposo, Luiz Sérgio
Maniglia, José Víctor
Pavarino-Bertelli, Érika Cristina
Goloni-Bertollo, Eny Maria

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Publication date

April 2011

DOI

10.1016/S2255-4823(11)70043-1

Publisher

Elsevier Editora Ltda. and Brazilian Medical Association.

Abstract

SummaryObjectiveTo investigate the MTHFD1 G1958A polymorphism involved in the folate metabolism as a risk for head and neck cancer, and to find the association of the polymorphism with the risk factors and clinical and histopathological characteristics.MethodsRetrospective study investigating MTHFD1 G1958A polymorphism in 694 subjects (240 patients in the Case Group and 454 in the Control Group) by Restriction Fragment Length Polymorphism (RFLP) Analysis. Multiple logistic regression and chi-square tests were used in the statistical analysis.ResultsMultivariable analysis showed that smoking and age over 42 years were disease predictors (p<0.05). MTHFD1 1958GA or AA genotypes were associated with smoking (p=0.04) and alcoholism (p=0.03) and ...