Two distinct polypeptides may be translated from a single spliced mRNA of the X genes of human T-cell leukemia and bovine leukemia viruses

AbstractHuman T-cell leukemia and bovine leukemia viruses have a potential transforming gene, termed X. In addition to the major open reading frame known to encode a functional protein, the X gene harbors another short open reading frame which overlaps this major one. Both of these open reading frames are found on a single spliced X mRNA in a potentially functional form. Circumstantial evidence strongly suggests that they are both translated from the single X mRNA molecule, showing striking similarity to the translation mechanism of an adenovirus Elb gene mRNA. We note that the short open reading frame has the capability to encode a putative nuclear protein with structural features similar to those of an AIDS virus trans-acting protein