ObjectiveUrokinase plasminogen activator (uPA) a key serine protease during remodeling, is capable of inducing both smooth muscle cell migration and proliferation. However, the signals that produce these responses are poorly understood.MethodsEarly passage rat aortic arterial smooth muscle cells were cultured in vitro and standard assays of DNA synthesis ([3H]thymidine incorporation), cell proliferation (manual cell counting), and migration (linear wound assay and Boyden chamber) were used to study the cells responses to uPA. Activation of the mitogen-activated protein kinases (MAPK), extracellular signal-regulated kinase 1/2 (ERK1/2), p38MAPK, Akt, MAP kinase/ERK kinase (MEK1/2), MAP kinase kinase (MKK)3/6, and epidermal growth factor rece...
Angiotensin II-induced growth of vascular smooth muscle cells requires an Src-dependent activation o...
Janus kinases Jak1 and Tyk2 play an important role in urokinase-type plasminogen activator (uPA)-dep...
Artículo de publicación ISIUrokinase-type plasminogen activator receptor (uPAR) and epidermal growth...
ObjectiveUrokinase plasminogen activator (uPA) a key serine protease during remodeling, is capable o...
AbstractBackgroundSingle-chain urokinase-type plasminogen activator (sc-uPA) is one of the key serin...
AbstractWe defined the role of urokinase plasminogen activator (uPA) and its growth factor-like doma...
BackgroundCell migration is an integral component of intimal hyperplasia development and proteases a...
IntroductionWe have previously demonstrated that transforming growth factor-β (TGF-β) in the presenc...
Urokinase (uPA)-induced signaling in human vascular smooth muscle cells (VSMC) elicits important cel...
AbstractWe defined the role of urokinase plasminogen activator (uPA) and its growth factor-like doma...
AbstractBackgroundSingle-chain urokinase-type plasminogen activator (sc-uPA) is one of the key serin...
Objective—The urokinase-type plasminogen activator (uPA) and its specific receptor (uPAR) are a pote...
The urokinase (uPA)/uPA receptor (uPAR) system plays a role in the response of the vessel wall to in...
AbstractPurpose: Mitogen-activated protein kinase (MAPK) is a ubiquitous signaling protein that has ...
IntroductionWe have previously demonstrated that transforming growth factor-β (TGF-β) in the presenc...
Angiotensin II-induced growth of vascular smooth muscle cells requires an Src-dependent activation o...
Janus kinases Jak1 and Tyk2 play an important role in urokinase-type plasminogen activator (uPA)-dep...
Artículo de publicación ISIUrokinase-type plasminogen activator receptor (uPAR) and epidermal growth...
ObjectiveUrokinase plasminogen activator (uPA) a key serine protease during remodeling, is capable o...
AbstractBackgroundSingle-chain urokinase-type plasminogen activator (sc-uPA) is one of the key serin...
AbstractWe defined the role of urokinase plasminogen activator (uPA) and its growth factor-like doma...
BackgroundCell migration is an integral component of intimal hyperplasia development and proteases a...
IntroductionWe have previously demonstrated that transforming growth factor-β (TGF-β) in the presenc...
Urokinase (uPA)-induced signaling in human vascular smooth muscle cells (VSMC) elicits important cel...
AbstractWe defined the role of urokinase plasminogen activator (uPA) and its growth factor-like doma...
AbstractBackgroundSingle-chain urokinase-type plasminogen activator (sc-uPA) is one of the key serin...
Objective—The urokinase-type plasminogen activator (uPA) and its specific receptor (uPAR) are a pote...
The urokinase (uPA)/uPA receptor (uPAR) system plays a role in the response of the vessel wall to in...
AbstractPurpose: Mitogen-activated protein kinase (MAPK) is a ubiquitous signaling protein that has ...
IntroductionWe have previously demonstrated that transforming growth factor-β (TGF-β) in the presenc...
Angiotensin II-induced growth of vascular smooth muscle cells requires an Src-dependent activation o...
Janus kinases Jak1 and Tyk2 play an important role in urokinase-type plasminogen activator (uPA)-dep...
Artículo de publicación ISIUrokinase-type plasminogen activator receptor (uPAR) and epidermal growth...